Uremic toxins originating from colonic microbial metabolism

Kidney International. Supplement
Pieter EvenepoelKristin Verbeke

Abstract

Numerous molecules, which are either excreted or metabolized by the kidney, accumulate in patients with chronic kidney disease (CKD). These uremic retention molecules (URMs), contributing to the syndrome of uremia, may be classified according to their site of origin, that is, endogenous metabolism, microbial metabolism, or exogenous intake. It is increasingly recognized that bacterial metabolites, such as phenols, indoles, and amines, may contribute to uremic toxicity. In vitro studies have implicated bacterial URMs in CKD progression, cardiovascular disease, and bone and mineral disorders. Furthermore, several observational studies have demonstrated a link between serum levels of bacterial URMs and clinical outcomes. Bacterial metabolism may therefore be an important therapeutic target in CKD. There is evidence that besides reduced renal clearance, increased colonic generation and absorption explain the high levels of bacterial URMs in CKD. Factors promoting URM generation and absorption include an increased ratio of dietary protein to carbohydrate due to insufficient intake of fiber and/or reduced intestinal protein assimilation, as well as prolonged colonic transit time. Two main strategies exist to reduce bacterial URM leve...Continue Reading

References

Jan 1, 1995·American Journal of Nephrology·T NiwaT Miyazaki
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gen YasudaOsamu Tochikubo
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Atsushi EnomotoToshimitsu Niwa
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fumio TakayamaToshimitsu Niwa
Apr 5, 2003·Kidney International·Raymond VanholderUNKNOWN European Uremic Toxin Work Group (EUTox)
Nov 25, 2003·Kidney International·Bert BammensPieter Evenepoel
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ming-Ju WuMing-Jer Tang
Aug 18, 2005·Kidney International·John C LieskeCynthia Regnier
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan T Kielstein, Carmine Zoccali
Aug 27, 2005·Journal of the American Society of Nephrology : JASN·Andres W MartinezTimothy W Meyer
Sep 30, 2005·Journal of the American Society of Nephrology : JASN·Nicolas AmabileChantal M Boulanger
Jan 18, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Hassan YounesJean-Claude Alphonse
Jan 26, 2006·American Journal of Physiology. Renal Physiology·Andrew K Gelasco, John R Raymond
Feb 24, 2006·Journal of Clinical Pharmacology·Jean-Francois MarierDaniel E Salazar
Mar 28, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gerald SchulmanNelson Kopyt
Apr 14, 2006·Kidney International·H YamamotoE Kusano
May 4, 2006·Molecular Nutrition & Food Research·Kieran M TuohyJennifer M Ames
Jul 6, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yoshiko IwasakiMasafumi Fukagawa
Sep 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vicky De PreterKristin Verbeke
Oct 17, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchepersRaymond Vanholder
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Douglas G Burrin, Barbara Stoll
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·David S GoldfarbJohn R Asplin
Sep 28, 2007·The New England Journal of Medicine·Timothy W Meyer, Thomas H Hostetter
Dec 6, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Atsushi Enomoto, Toshimitsu Niwa
Feb 29, 2008·Kidney International·B K I MeijersP Evenepoel
Mar 13, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ayinuer AdijiangToshimitsu Niwa
Apr 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Björn K I MeijersPieter Evenepoel
May 2, 2008·Annals of the New York Academy of Sciences·Helen VlassaraGary Striker
Jun 25, 2008·Seminars in Dialysis·Tina Neade, Jaime Uribarri
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak

❮ Previous
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Citations

Feb 2, 2013·Chinese Journal of Integrative Medicine·Chuan ZouXu-Sheng Liu
Jul 8, 2010·Nature Reviews. Nephrology·Shayan Shirazian, Jai Radhakrishnan
Sep 21, 2011·Seminars in Dialysis·Timothy W MeyerThomas H Hostetter
Dec 7, 2011·Seminars in Dialysis·Raymond VanholderZiad Massy
Aug 19, 2011·Artificial Organs·Ioannis GriveasSotiris Vrachnes
Dec 20, 2011·Applied and Environmental Microbiology·I-Kuan WangHung-Chih Lin
Oct 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henrike M HamerKristin Verbeke
Jun 16, 2012·International Journal of Nephrology·Emilio González-ParraAlberto Ortiz
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Pavel A AronovTimothy W Meyer
Oct 2, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Mirela DobreThomas H Hostetter
Oct 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ilian O MarquezTimothy W Meyer
Apr 12, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Kajal P PatelTimothy W Meyer
Sep 24, 2013·Journal of Pharmacological and Toxicological Methods·B H AliA Nemmar
May 2, 2014·Seminars in Nephrology·Rosalinde MasereeuwJerome Lowenstein
May 2, 2014·Seminars in Nephrology·Björn MeijersStephan J L Bakker
Jan 15, 2013·International Journal of Nephrology·Megan RossiKatrina L Campbell
Feb 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn K I Meijers, Pieter Evenepoel
Dec 23, 2015·International Journal of Molecular Sciences·Mario BonominiAndrea Urbani
May 3, 2013·Kidney International·Tammy L SirichTimothy W Meyer
Feb 10, 2012·Kidney International·Timothy W Meyer, Thomas H Hostetter
Jun 19, 2014·Kidney International·Dalia El-GamalGunther Marsche
Sep 17, 2015·Kidney International·Laetitia KoppeDenis Fouque
Jan 14, 2012·Kidney International·Pieter Evenepoel, Björn K Meijers
Jan 18, 2013·Kidney International·Hans-Joachim AndersBärbel Stecher
Mar 29, 2011·Seminars in Nephrology·Bert Bammens
May 3, 2011·Journal of Pharmaceutical and Biomedical Analysis·Xin QiWei Jia
Oct 6, 2015·Journal of Cardiac Failure·Yuji Nagatomo, W H Wilson Tang
Mar 12, 2016·Clinical and Experimental Nephrology·David BriskeyJeff S Coombes
May 7, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ana Paula BlackDenise Mafra
Mar 24, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shunsuke GotoMasafumi Fukagawa
Mar 2, 2013·Molecular Nutrition & Food Research·Luis Vitetta, Glenda Gobe
Jan 6, 2011·Molecular Nutrition & Food Research·Vicky De PreterKristin Verbeke
Nov 15, 2011·Journal of Animal Physiology and Animal Nutrition·S DepauwG P J Janssens
Jun 26, 2014·Seminars in Dialysis·Moshe ShasharVipul Chitalia
Dec 3, 2014·Seminars in Dialysis·Raymond VanholderSunny Eloot
Aug 25, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Laura Rodríguez-OsorioEmilio González Parra
Dec 3, 2014·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Daniela Viramontes-HörnerGuillermo García-García
Oct 17, 2014·Seminars in Dialysis·Tammy L Sirich
Sep 18, 2015·Frontiers in Medicine·Henricus A M MutsaersPeter Olinga

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Next ❯

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