Ureteral ischemia model: an explanation of ureteral dysfunction after chronic obstruction

Journal of Endourology
Caner Z DinlencA D Smith

Abstract

Many models of smooth muscle ischemia have been developed to explain organ insufficiency or failure. Ureteral decompensation may also be described in these terms. We anticipate that ureteral ischemia will result from overdistention brought about by obstruction. A preliminary model of an ischemic ureter is described herein. Six female New Zealand rabbits were used for this study. All had their left ureters surgically ligated at the level of the urinary bladder. The right ureters served as controls. In the acute-phase group, the ureters were reexplored 2 weeks after creation of obstruction. The other three rabbits were explored 3 weeks later. A laser Doppler needle was used to measure tissue perfusion with bilateral measurements of the renal artery and vein; renal parenchyma; renal pelvis; ureteropelvic junction; upper, mid, and lower ureter; and the lateral wall of the bladder. Baseline and postobstructive measurements of tissue perfusion were collected. In both the acute and chronic obstruction groups, there was a demonstrable drop-off in perfusion of the ureteral wall. The increased wall tension in the obstructed ureter results in a significant decrease in smooth muscle perfusion. This ischemia may result in the same functiona...Continue Reading

References

Aug 1, 1978·Urology·J G Rose, J Y Gillenwater
Aug 1, 1976·The American Journal of Physiology·P BiancaniR M Weiss
Feb 1, 1975·British Journal of Urology·M Dunn
Feb 1, 1984·The Journal of Urology·S TokunakaN Miyabe
Jul 1, 1953·The Journal of Pathology and Bacteriology·R M MEHROTRA

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Citations

Aug 15, 2006·Journal of Endourology·Hyeong Gon KimYong Soo Lho
Mar 17, 2016·World Journal of Nephrology·Maximilien BaronJean-Nicolas Cornu

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