Abstract
Anesthesia in rats produced by urethane administered intraperitoneally caused (1) peritoneal fluid accumulation; (2) inability to undergo a renal response to NaCl or water loading, and (3) pronounced hyperosmolality of body fluids without affecting plasma [Na+]. The impairment of the renal function appears not to be due to anesthesia per se, angiotensin, aldosterone, vasopressin or renal nerves. It probably is attributable to osmotoxicity of the mesenteric vasculature. By contrast, urethane administered intravenously evokes a brisk osmotic diuresis without fluid leakage into the peritoneum. Plasma osmolality is still increased. The osmotic toxicity to the mesenteric vasculature, poor renal function and altered composition of body fluids that occur after intraperitoneal urethane may complicate the interpretation of data obtained in rats anesthetized in this manner.
Citations
Dec 22, 1999·Neurourology and Urodynamics·S Matsuura, J W Downie
May 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Charlotte W UsselmanJ Kevin Shoemaker
Mar 15, 1986·Experientia·C A Maggi, A Meli
Jan 1, 1991·Dysphagia·D Bieger
Oct 1, 1990·The Journal of Pharmacy and Pharmacology·M GumbletonG Taylor
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John N Lorenz
Mar 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J A Watt, R G Dickinson
Jan 28, 2006·Synapse·Elaine M JagodaWilliam C Eckelman
Feb 18, 2016·Journal of Diabetes Research·Kenneth N GriséC W James Melling
May 15, 1986·Experientia·C A Maggi, A Meli
Jan 15, 1984·Experientia·C A MaggiA Meli
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ben J A JanssenThomas L Smith
Feb 15, 1986·Experientia·C A Maggi, A Meli
Mar 27, 2021·Drug Metabolism and Personalized Therapy·Nazar M KostyshynStepan I Mudry
Feb 19, 2021·Endocrine Regulations·Nazar M KostyshynStepan I Mudry
Sep 1, 1989·Neuropharmacology·M A Hashim, D Bieger
Dec 1, 1982·Toxicology Letters·D L Eaton
May 18, 2010·Neuroscience Letters·Dmitry V ZaretskyJoseph A DiMicco