Urethral pain syndrome: fact or fiction--an update

Der Urologe. Ausg. A
N M DregerD A Lazica

Abstract

Urethral pain syndrome is a symptom complex including dysuria, urinary urgency and frequency, nocturia and persistent or intermittent urethral and/or pelvic pain in the absence of proven infection. These symptoms overlap with several other conditions, such as interstitial cystitis bladder pain syndrome and overactive bladder. Urethral pain syndrome may occur in men but is more frequent in women. The exact etiology is unknown but infectious and psychogenic factors, urethral spasms, early interstitial cystitis, hypoestrogenism, squamous metaplasia as well as gynecological risk factors are discussed. These aspects should be ruled out or confirmed in the diagnostic approach. Despite the assumption of a multifactorial etiology, pathophysiologically there is a common pathway: dysfunctional epithelium of the urethra becomes leaky which leads to bacterial and abacterial inflammation and ends in fibrosis due to the chronic impairment. The therapeutic approach should be multimodal using a trial and error concept: general treatment includes analgesia, antibiotics, alpha receptor blockers and muscle relaxants, antimuscarinic therapy, topical vaginal estrogen, psychological support and physical therapy. In cases of nonresponding patients in...Continue Reading

References

May 19, 1979·Lancet·R MaskellJ Allen
Jan 1, 1977·European Urology·H Lipsky
Apr 1, 1976·The Journal of Urology·S Raz, R B Smith
Jun 1, 1992·Journal of Behavioral Medicine·A M BernsteinH Fenster
Oct 1, 1985·British Journal of Urology·J TaitA F Burry
Jul 1, 1988·The Journal of Urology·R Perez-MarreroJ T Feltis
May 1, 1987·The Journal of Urology·S C MuellerH J Rumpelt
Feb 1, 1984·Urology·G A Barbalias, E M Meares
Aug 21, 1980·The New England Journal of Medicine·W E StammK K Holmes
Apr 16, 1981·The New England Journal of Medicine·W E StammK K Holmes
Dec 1, 1981·American Journal of Obstetrics and Gynecology·C S IosifB Astedt
Jul 1, 1980·The Journal of Urology·W E KaplanH W Schoenberg
Apr 1, 1995·Perceptual and Motor Skills·F BaldoniG Trombini
May 1, 1994·British Journal of Urology·C L ParsonsD Lebow
Apr 30, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H GürelM K Atilla
Jul 4, 2001·The Journal of Urology·O RofeimR M Moldwin
Oct 29, 2002·Yonsei Medical Journal·Sang Min YoonTack Lee
Feb 1, 2003·Urology·Paul AbramsUNKNOWN Standardisation Sub-Committee of the International Continence Society
Jul 5, 2003·Science·Gregory G AndersonScott J Hultgren
Mar 6, 1965·British Medical Journal·D J GALLAGHERJ D NORTH
Feb 24, 2006·Urologia Internationalis·Elisabetta CostantiniLuigi Mearini
Apr 12, 2007·Obstetrical & Gynecological Survey·Hervinder Kaur, Angamuthu S Arunkalaivanan
Sep 8, 2009·European Urology·Magnus FallUNKNOWN European Association of Urology
May 1, 2009·Journal of Pelvic Medicine & Surgery·Megan KrauseHolly E Richter
Jan 23, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Harris PhillipVictor Chilaka

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Citations

Mar 12, 2016·Current Opinion in Urology·Jane T KurtzmanJeffrey P Weiss
Oct 28, 2020·Diagnostics·Olga StreltsovaElena Kiseleva

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