Urethral recurrence in women with orthotopic bladder substitutes: A multi-institutional study

Urologic Oncology
Georgios GakisArnulf Stenzl

Abstract

To evaluate risk factors for urethral recurrence (UR) in women with neobladder. From 1994 to 2011, 297 women (median age = 54 y; interquartile range: 47-57) underwent radical cystectomy with ileal neobladder for bladder cancer in 4 centers. None of the patients had bladder neck involvement at preoperative assessment. Univariable and multivariable analyses were used to estimate recurrence-free survival and overall survival. The median follow-up was 64 months (interquartile range: 25-116). Of the 297 patients, 81 developed recurrence (27%). The 10- and 15-year recurrence-free survival rates were 66% and 66%, respectively. The 10- and 15-year overall survival rates were 57% and 55%, respectively. UR occurred in 2 patients (0.6%) with solitary urethral, 4 (1.2%) with concomitant urethral and distant recurrence, and 1 with concomitant urethral and local recurrence (0.3%). Bladder tumors were located at the trigone in 27 patients (9.1%). None of these patients developed UR. Lymph node tumor involvement was present in 60 patients (20.2%). On univariable and multivariable analyses, pathologic tumor and nodal stage were independent predictors for the overall risk of recurrence. UR was associated with a positive final urethral margin sta...Continue Reading

References

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Jul 16, 2013·Current Opinion in Urology·Tilman TodenhöferChristian Schwentner

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Citations

Mar 2, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M MoschiniR Colombo
Jul 12, 2016·Critical Reviews in Oncology/hematology·Barbara Alicja Jereczek-FossaRoberto Orecchia
Oct 9, 2016·The Urologic Clinics of North America·Kamran Zargar-ShoshtariMichael A Poch
Oct 11, 2016·European Urology·Georgios GakisWassim Kassouf
Apr 18, 2018·Neurourology and Urodynamics·Gillian StearnsJaspreet Sandhu
Sep 17, 2015·Current Opinion in Urology·Georgios Gakis, Arnulf Stenzl
Mar 12, 2017·Current Urology Reports·Nathan Y HoyRoger R Dmochowski
Nov 30, 2019·Current Urology Reports·Nikolaos KalampokisGeorgios Gakis
Apr 3, 2020·Current Opinion in Urology·Roberto CarandoDavid D'Andrea

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