Urethral replacement with vascularized tunica vaginalis: defining the optimal form of use

The Journal of Urology
D TheodorescuA E Khoury

Abstract

Residual urethral defects after failed hypospadias surgery present difficulties in reconstruction. In these situations, repair using vascularized tissue flaps remains ideal, yet challenging. In order to offer more surgical alternatives in these cases, the use of vascularized tunica vaginalis flaps as urethral replacements has recently been established in an animal model. We undertook the following studies to further define the role of tunica vaginalis in urethral reconstruction. A vascularized flap of tunica vaginalis was used to replace an experimentally created 25-30 mm. gap in the anterior urethra of 26 rabbits, either as an onlay or tube flap. A control group consisting of 7 animals underwent only a segmental anterior urethral resection and primary re-anastomosis. Satisfactory urethral healing occurred in all control animals that survived the procedure. All 8 animals which had tunica vaginalis tube flap reconstruction underwent contracture of the neourethra probably secondary to the presence of striated cremasteric muscle elements brought with the tunica during mobilization. All 16 animals available for long term study in the onlay flap group had excellent flap viability and 100% urethral patency rates. The mesothelial lini...Continue Reading

References

Apr 1, 1989·British Journal of Urology·A E KhouryJ W Costerton
Aug 1, 1989·The Journal of Urology·A E KhouryB M Churchill
Dec 1, 1995·British Journal of Urology·L S Baskin, J W Duckett

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Citations

Dec 10, 2002·Journal of Endourology·Paul RotariuArthur D Smith
Feb 4, 2011·Tissue Engineering. Part a·Gabrielle OuelletStéphane Bolduc
Dec 29, 2006·Urologia Internationalis·Gabriela Ambriz-GonzálezJaime Vargas Basterra
Aug 2, 2011·Research in Veterinary Science·T SrithunyaratM Kalpravidh
Jun 15, 2010·Research in Veterinary Science·P WongsetthachaiM Kalpravidh
Jan 1, 2014·Lower Urinary Tract Symptoms·Abdul-Ali YaqubiJin Tie Xiong
Dec 11, 2003·The Journal of Urology·Ahmed ShokeirMahmoud el-Baz
Aug 24, 1999·The Journal of Urology·A AtalaA B Retik
Jul 12, 2005·The Journal of Urology·Adriano A CaladoMiguel Srougi
Dec 13, 2002·The Journal of Urology·Abdel W El-KassabyAnthony Atala
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R C LaraS Arap
Sep 2, 2020·Anatomia, histologia, embryologia·Joanna SkoniecznaRomuald Będziński
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Tariq O AbbasCristian Pablo Pennisi
Aug 31, 2021·Frontiers in Pediatrics·Tariq O AbbasAbdulla Alnaimi

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