Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study

Journal of Hypertension
Lieke E J M ScheepersIlja C W Arts

Abstract

Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension. Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 ± 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension. After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated with higher 24-h MAP [β 0.63 mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140 mg/day/1.73 m) was associated with higher 24-h MAP (β 0.79 mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no si...Continue Reading

References

Oct 1, 1988·The American Journal of Medicine·J G PuigT H Ramos
Jan 1, 1985·American Journal of Epidemiology·F N BrandW P Castelli
Jul 17, 1998·Mathematical Biosciences·R CurtoM Cascante
May 18, 1999·Cardiovascular Research·M J Mulvany
Sep 6, 2002·Journal of Human Hypertension·E CasigliaA C Pessina
Sep 7, 2002·Hypertension·Susumu WatanabeRichard J Johnson
Mar 12, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Taku InoueShuichi Takishita
Apr 26, 2003·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Sep 19, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jacques ChanardBruno Moulin
May 24, 2006·Atherosclerosis·Nobukazu IshizakaMinoru Yamakado
Aug 2, 2008·American Journal of Hypertension·Toshihiro HamadaIchiro Hisatome
Jan 16, 2010·American Journal of Hypertension·Xin ChenJi-Guang Wang
Jul 29, 2010·Korean Circulation Journal·Ji Hyon LimMyoung-Mook Lee
Sep 9, 2010·Arthritis Care & Research·Peter C GraysonHyon K Choi
Oct 18, 2011·Metabolism: Clinical and Experimental·Juan G PuigJosé R Banegas
Jun 8, 2012·The Journal of Clinical Hypertension·Daniel I Feig
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Mar 5, 2013·International Journal of Cardiology·Pai-Feng HsuChen-Huan Chen
Aug 6, 2013·The Journal of Biological Chemistry·Yu TsushimaIichiro Shimomura
Jun 19, 2014·Nucleosides, Nucleotides & Nucleic Acids·Hirotaka MatsuoKimiyoshi Ichida
Jun 19, 2014·Nucleosides, Nucleotides & Nucleic Acids·Tappei TakadaHiroshi Suzuki
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Jan 30, 2015·Nucleic Acids Research·Andrew N Lane, Teresa W-M Fan

❮ Previous
Next ❯

Citations

Feb 15, 2021·European Journal of Preventive Cardiology·Paolo PalatiniUNKNOWN from the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
Mar 30, 2021·Clinical and Experimental Hypertension : CHE·Chunying LiuHuocheng Liao
May 1, 2021·International Journal of Molecular Sciences·Barbora BoťanskáMiroslav Barančík
May 11, 2020·Journal of the Neurological Sciences·Aniqa B AlamAlvaro Alonso

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.