Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation

Current Neurovascular Research
Irene CiancarelliMaria Giuliana Tozzi Ciancarelli

Abstract

No evidence is currently provided on the involvement of uric acid (UA) and Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in functional recovery of stroke patients after neurorehabilitation. For this purpose, the relationship between UA and Cu/Zn SOD plasma levels and clinical and functional outcome measures were analysed in twenty-five post-acute stroke patients undergoing intensive neurorehabilitation. UA and Cu/Zn SOD plasma levels were evaluated in fifteen healthy subjects as control values. Neurorehabilitation was associated with improved scores (P<0.05) of the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the mPULSES profile. UA plasma levels were higher before neurorehabilitation, decreased after, but were still higher than control values. Conversely, Cu/Zn SOD plasma levels were lower than control values before neurorehabilitation and increased after, even though the absolute values were still lower than controls. An inverse correlation was found between variations of UA plasma levels observed before and after neurorehabilitation (Δ UA) and those of Cu/Zn SOD (Δ Cu/Zn SOD) (r= -0.386; P<0.001). No significant correlations were observed between ΔUA and the variations of the scores obser...Continue Reading

Citations

Feb 16, 2019·Journal of Cellular Physiology·Wan-Gen LiuRong Xiang
Apr 25, 2018·Frontiers in Neurology·Marianna SempriniMichela Chiappalone
Dec 24, 2018·Aging and Disease·Ashok K ShettyLeelavathi N Madhu
Jul 20, 2019·Brain Research Bulletin·Gisele E BruchAndré R Massensini

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