Uric acid and obesity-related phenotypes in postmenopausal women

Molecular and Cellular Biochemistry
Bogna Grygiel-GórniakJ Nowak

Abstract

The aim of this study was to find the genetic, metabolic, and nutritional risk factors, which can be associated with uric acid (UA) level. The risk factors related to uricemia were assessed among 271 postmenopausal women without cardiometabolic disorders and hypolipidemic/hypoglycemic treatment selected from a cohort of 1423 obese postmenopausal women. The bioimpedance analysis and biochemical and genetic analyses were performed in two groups characterized by serum UA ≥ 4 mg/dL (238 μmol/L) and < 4 mg/dL. The TaqMan-based real-time PCR method was applied to assess the role of Pro12Ala of peroxisome proliferation-activated receptor (PPAR)gamma-2 and Trp64Arg of beta-3-adrenergic receptor (ADRB) polymorphisms. Women with UA level ≥ 4 mg/dL were characterized by larger body mass, triceps skinfold, waist circumference, body fat amount, and serum insulin, glucose, and triglyceride levels. There was no difference in dietary habits between the analyzed groups. Body mass, waist circumference, body fat amount, diastolic blood pressure, and serum insulin, glucose, high-density lipoprotein, and triglyceride levels, Homeostasis Model Assessment-Insulin Resistance, and energy from the dietary fat influence the UA level ≥ 4 mg/dL; however, t...Continue Reading

References

Oct 4, 2000·Nature Genetics·D AltshulerL Kruglyak
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 3, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B ZietzA Schäffler
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Feb 27, 2003·Journal of Physiology and Biochemistry·M GarauletF J Tebar
Mar 5, 2004·Journal of the American College of Cardiology·Lori MoscaUNKNOWN World Heart Federation
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
May 6, 2006·Stroke; a Journal of Cerebral Circulation·Michiel J BosMonique M B Breteler
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Dec 1, 2007·Climacteric : the Journal of the International Menopause Society·P CollinsM Stramba-Badiale
Mar 4, 2008·Diabetes Research and Clinical Practice·Takeyuki NumataHirofumi Makino
Jun 14, 2008·Menopause : the Journal of the North American Menopause Society·Mónica Ramírez-SalazarJuan Manuel Malacara
Jul 19, 2008·The New England Journal of Medicine·Iris ShaiUNKNOWN Dietary Intervention Randomized Controlled Trial (DIRECT) Group
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Dec 17, 2009·The Journal of Rheumatology·Sonsoles MorcilloFederico Soriguer
Jan 15, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Apr 7, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Dimitry A ChistiakovValery V Nosikov
Jun 22, 2010·Scandinavian Journal of Rheumatology·C-F KuoL-C See
Jun 30, 2011·European Heart Journal·UNKNOWN European Association for Cardiovascular Prevention & RehabilitationUNKNOWN ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees
Jan 25, 2013·Heart·Mehmet KanbayRichard J Johnson
Feb 26, 2013·The New England Journal of Medicine·Ramón EstruchUNKNOWN PREDIMED Study Investigators
Sep 28, 2014·Clinical Hemorheology and Microcirculation·Amparo VayáBegoña Laiz
Aug 12, 2015·Mayo Clinic Proceedings·Tracey L WeissgerberVesna D Garovic
Sep 1, 2015·International Journal of Cardiology·Jessica MaiuoloVincenzo Mollace
Feb 26, 2016·Archives of Gerontology and Geriatrics·Shaochen GuanChengbei Hou
Mar 24, 2016·Kardiologia polska·Tomasz ZdrojewskiBogdan Wyrzykowski
Oct 30, 2016·Lancet·Nicola DalbethLisa K Stamp

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Haploview

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