Uric acid and xanthine oxidase in heart failure - Emerging data and therapeutic implications

International Journal of Cardiology
W DoehnerS D Anker

Abstract

The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for decades. While the association of elevated uric acid (UA) levels with increased mortality risk as convincingly been shown, the question whether UA is independently predictive of just a related effect within a more complex risk factor profile (including metabolic, inflammatory and haemodynamic risk factors) is still a matter of dispute. In heart failure the independent prognostic and functional impact of elevated UA has not only been shown but also the pathophysiologic mechanism(s) and the potential of targeted therapeutic interventions have been investigated in some detail. The emerging picture suggests the increased activity of the enzyme xanthine oxidase (XO) with corresponding increased production of free oxygen radical (ROS) as a main underlying principle with the resulting increase in UA levels being mostly a marker of this up-regulated pathway. While this concept will not diminish the value of UA as a prognostic marker, it provides the basis for a novel metabolic treatment option and the means to identify those patients most eligible for this tailored therapy. This review will summarize the recent evidence on XO as a novel and promi...Continue Reading

References

Sep 29, 1998·Metabolism: Clinical and Experimental·F LeyvaA J Coats
Jul 10, 2002·Circulation·Colin A J FarquharsonAllan D Struthers
Sep 20, 2005·Journal of the American College of Cardiology·Wolfram DoehnerStefan D Anker
Oct 11, 2005·Free Radical Biology & Medicine·Stephan BaldusThomas Münzel
Dec 13, 2005·The New England Journal of Medicine·Michael A BeckerNancy Joseph-Ridge
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Jun 20, 2006·International Journal of Cardiology·Ewa A JankowskaPiotr Ponikowski
Jul 18, 2006·International Journal of Cardiology·Wolfram DoehnerStefan D Anker
Sep 6, 2006·Journal of Cardiac Failure·Horacio E CingolaniNéstor G Pérez
Oct 27, 2006·European Journal of Heart Failure·Domingo A Pascual-FigalMariano Valdes
Apr 17, 2007·European Journal of Heart Failure·Wolfram DoehnerStefan D Anker
Feb 25, 2009·European Journal of Internal Medicine·Anna L AlimondaAngel Llácer
Nov 13, 2009·Rheumatology·N Lawrence Edwards
Aug 21, 2009·International Journal of Clinical Practice·L WeiT M MacDonald
Aug 11, 2010·Archives of Internal Medicine·George ThanassoulisLouise Pilote
Jan 29, 2011·Congestive Heart Failure·Leonardo TamarizJoshua Hare
Apr 2, 2011·European Journal of Heart Failure·Luis ManzanoUNKNOWN SENIORS Investigators
Feb 18, 2012·International Journal of Cancer. Journal International Du Cancer·Jochen SpringerWolfram Doehner
Aug 23, 2012·Journal of Cachexia, Sarcopenia and Muscle·Jean-Christophe PeterKarl G Hofbauer
Jan 12, 2013·Journal of Cachexia, Sarcopenia and Muscle·Aurelius OmlinFlorian Strasser
Mar 30, 2013·Journal of Cachexia, Sarcopenia and Muscle·Jerneja FarkasMitja Lainscak
May 15, 2013·The International Journal of Biochemistry & Cell Biology·Stephan von HaehlingStefan D Anker
Jun 12, 2013·International Journal of Cardiology·Jochen SpringerWolfram Doehner
Jun 26, 2013·Journal of Cachexia, Sarcopenia and Muscle·Dirk HabedankRalf Ewert
Jul 19, 2013·Circulation. Heart Failure·Michael M GivertzEugene Braunwald
Nov 26, 2013·Journal of Cachexia, Sarcopenia and Muscle·Mareike S PötschJochen Springer
Feb 15, 2014·Journal of Cachexia, Sarcopenia and Muscle·John E MorleyBruno Vellas
Mar 7, 2014·Journal of Cachexia, Sarcopenia and Muscle·Nicole EbnerStephan von Haehling
Mar 29, 2014·Journal of Cachexia, Sarcopenia and Muscle·Patrícia Lopes de Campos-FerrazAntonio Herbert Lancha

❮ Previous
Next ❯

Citations

Apr 5, 2016·The American Journal of Cardiology·Alberto PalazzuoliPeter A McCullough
Nov 26, 2015·Journal of the American Medical Directors Association·Stephan von Haehling, Jochen Springer
Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Feb 5, 2019·Scandinavian Cardiovascular Journal : SCJ·Péter PergeGábor Széplaki
Mar 30, 2019·Current Opinion in Cardiology·Matteo Landolfo, Claudio Borghi
Dec 12, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Elissa DrigginMathew S Maurer
Sep 22, 2017·Interventional Medicine & Applied Science·András Mihály BorosGábor Széplaki
Jul 26, 2017·Journal of Cardiovascular and Thoracic Research·Mohammad Mostafa Ansari-RamandiNasim Naderi
Jul 13, 2017·Oxidative Medicine and Cellular Longevity·Ilaria MarroccoIlaria Peluso
Nov 12, 2016·Antioxidants & Redox Signaling·Lucia M LeitnerAxel Gödecke
Dec 28, 2019·International Journal of Molecular Sciences·Spencer G MillerJeffrey J Brault
Nov 27, 2020·European Journal of Preventive Cardiology·Andrea TedeschiMassimo F Piepoli
Jan 21, 2021·Free Radical Biology & Medicine·Yoshiro TanakaMichihiro Yoshimura
May 22, 2021·Free Radical Biology & Medicine·David Weissman, Christoph Maack
Jul 13, 2021·Cardiology Clinics·Davide AgnolettiClaudio Borghi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.