Uric acid as a cardiorenal mediator: pathogenesis and mechanistic insights.

Expert Review of Cardiovascular Therapy
Asma GulabJanani Rangaswami

Abstract

Introduction: The role of serum uric acid as a connector in cardiorenal interactions has been long debated and studied extensively in the past decade. Epidemiological, and clinical data suggest that hyperuricemia may be an independent risk factor as well as a strong predictor of morbidity and mortality in cardiovascular diseases (CVD) and renal diseases. New data suggesting that urate lowering therapies may improve outcomes in cardiovascular diseases have generated interest.Areas Covered: This review attempts to summarize the pathophysiological mechanisms by which hyperuricemia causes cardiorenal dysfunction. It also provides a summary of the recent evidence for urate lowering therapies and the possible underlying mechanisms which lead to cardiovascular benefits. This was a narrative review with essential references or cross references obtained via expert opinion.Expert Opinion: Emphasis on newer drugs that address the cardio-renal metabolic axis and the relation to their effects on uric acid may help further elucidate underlying mechanisms responsible for their cardiovascular and renal benefits. Once these benefits are well established, we will be able to come up with guidelines for targeting hyperuricemia. This can potentiall...Continue Reading

References

Jan 1, 1992·European Journal of Clinical Pharmacology·M NakashimaM Kanamaru
Oct 1, 1980·Annals of the Rheumatic Diseases·L F Sorensen
Aug 26, 1998·American Journal of Hypertension·G De MattiaC Ferri
Dec 21, 2000·American Journal of Physiology. Cell Physiology·D A SiwikW S Colucci
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Françoise Roch-Ramel, Barbara Guisan
Aug 7, 2001·Journal of Cardiovascular Pharmacology·W S WaringS R Maxwell
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
May 9, 2002·American Journal of Physiology. Renal Physiology·Marilda MazzaliRichard J Johnson
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Feb 12, 2004·Kidney International·Aud HøieggenUNKNOWN LIFE Study Group
Sep 27, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Anna V NaumovaRobert G Weiss
Sep 6, 2006·Journal of Cardiac Failure·Horacio E CingolaniNéstor G Pérez
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohamed E SulimanPeter Stenvinkel
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michel ChoncholLinda F Fried
Jun 14, 2008·Journal of the American College of Cardiology·Joshua M HareUNKNOWN OPT-CHF Investigators
Aug 2, 2008·American Journal of Hypertension·Toshihiro HamadaIchiro Hisatome
Jan 16, 2009·Journal of the American Society of Nephrology : JASN·René R WenzelUNKNOWN SPP301 (Avosentan) Endothelin Antagonist Evaluation in Diabetic Nephropathy Study Investigators
Feb 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotsugu MitsuhashiKoji Tamakoshi
Mar 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Magdalena MaderoVandana Menon
Feb 20, 2010·Journal of the American Society of Nephrology : JASN·Johannes F E MannUNKNOWN ASCEND Study Group
Dec 15, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Douglas GreigSergio Lavandero
Jan 26, 2011·Journal of Cardiovascular Disease Research·Gamela Nasr, Cherine Maurice
Mar 1, 2012·Journal of the American College of Cardiology·Glenn A HirschRobert G Weiss
May 9, 2012·Journal of Molecular and Cellular Cardiology·Sheryl E KochJack Rubinstein
Dec 14, 2012·Nephron. Experimental Nephrology·Laura Gabriela Sánchez-LozadaRichard J Johnson
Dec 21, 2013·Current Rheumatology Reports·Miguel A MartilloDaria B Crittenden
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Dick de ZeeuwHans-Henrik Parving
Apr 23, 2014·American Journal of Nephrology·Mehmet KanbayAdrian Covic
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
May 20, 2015·Circulation·Leonardo Tamariz, Joshua M Hare
Aug 21, 2015·Nephro-urology Monthly·Om Shankar Prasad Sah, Yu Xue Qing
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
Oct 13, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Carlos Roncal-JimenezRichard J Johnson

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