Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance

American Heart Journal
Wolfram DoehnerS D Anker

Abstract

Chronic heart failure (CHF) is a hyperuricemic state, and capillary endothelium is the predominant site of xanthine oxidase in the vasculature. Upregulated xanthine oxidase activity (through production of toxic free radicals) may contribute to impaired regulation of vascular tone in CHF. We aimed to study the relationship between serum uric acid levels and leg vascular resistance in patients with CHF with and without cachexia and in healthy control subjects. In 23 cachectic and 44 noncachectic patients with CHF (age, 62 +/- 1 years, mean +/- SEM) and 10 healthy control subjects (age, 68 +/- 1 years), we assessed leg resting and postischemic peak vascular resistance (calculated from mean blood pressure and leg blood flow by venous occlusion plethysmography). Cachectic patients, compared with noncachectic patients and control subjects, had the highest uric acid levels (612 +/- 36 vs 459 +/- 18 and 346 +/- 21 micromol/L, respectively, both P <.0001) and the lowest peak leg blood flow and vascular reactivity (reduction of leg vascular resistance from resting to postischemic conditions: 83% vs 88% and 90%, both P <.005). In all patients, postischemic vascular resistance correlated significantly and independently of age with uric aci...Continue Reading

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Citations

Jul 18, 2006·International Journal of Cardiology·Wolfram DoehnerStefan D Anker
Jun 20, 2006·International Journal of Cardiology·Ewa A JankowskaPiotr Ponikowski
Nov 8, 2015·International Journal of Cardiology·Goran LoncarMitja Lainscak
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Sep 27, 2014·Journal of the American College of Cardiology·Wolfram DoehnerStefan D Anker
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