Uric acid is a useful marker to differentiate between responsive and refractory status epilepticus

Clinical Neurology and Neurosurgery
Jun Young ChoiKyoon Huh

Abstract

Early recognition of refractory status epilepticus (RSE) is essential to select an appropriate treatment strategy and is closely associated with the outcome. Only few studies of RSE biomarkers exist; hence, we investigated the serum levels of uric acid (UA), albumin, and C-reactive protein (CRP) as potential serologic biomarkers for RSE. Consecutive status epilepticus (SE) patients who had serial conventional blood tests in a referral hospital over a period of 10 years were retrospectively analyzed. Patients with anoxic encephalopathy, renal failure, acute stroke, and myocardial infarction were excluded. RSE was defined as seizure continuing after the first- and second-line treatments. We also assessed SE severity in all included patients using the Status Epilepticus Severity Score (STESS). General demographics and blood test findings were compared between responsive SE and RSE patients. A total of 141 patients (99 responsive and 42 refractory) were recruited from our SE registry. Compared to responsive patients, patients with RSE showed a higher STESS, lower initial albumin levels, lower initial UA levels, lower follow-up UA levels, and greater reduction of UA levels. The RSE group more frequently had acute symptomatic etiolog...Continue Reading

References

Aug 1, 1977·Annals of the Rheumatic Diseases·L RamsayJ Shelton
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Jun 1, 1997·European Journal of Clinical Investigation·S R MaxwellA H Barnett
Apr 18, 2003·Neuroscience·M Patel, Q Y Li
Aug 17, 2004·Epilepsy Currents·Carl E. Stafstrom
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gregory J QuinlanTimothy W Evans
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Sep 5, 2008·Journal of Neurology·Andrea O RossettiEdward B Bromfield
Oct 13, 2009·Epilepsia·Jan NovyAndrea O Rossetti
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel
Mar 6, 2010·Cerebrovascular Diseases·Ji Man HongBruce Ovbiagele
Jul 31, 2010·Neuron·Michael A MoskowitzCostantino Iadecola
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Sachin JainSania Naseem
Jan 16, 2013·JAMA Neurology·Sara E HockerAlejandro A Rabinstein
Feb 5, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·L J HirschF W Drislane
Mar 20, 2013·Critical Care Medicine·Raoul SutterStephan Marsch
Aug 7, 2013·Nature Reviews. Neurology·Raoul SutterStephan Rüegg
Aug 12, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R SutterW C Ziai
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Nobustune IshikawaMasao Kobayashi
Dec 17, 2014·Epileptic Disorders : International Epilepsy Journal with Videotape·Omar I KhanVijay M Thadani
Jan 30, 2015·Annals of Neurology·Sergio AmaroÁngel Chamorro
Jul 8, 2015·Epilepsy & Behavior : E&B·Eugen Trinka, Markus Leitinger
Aug 11, 2015·Open Forum Infectious Diseases·Anurag Markanday
Oct 10, 2015·Critical Care : the Official Journal of the Critical Care Forum·Raoul SutterStephan Marsch

❮ Previous
Next ❯

Citations

Sep 6, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ayham AlkhachroumJan Claassen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.