Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures

Experimental Neurology
Lisa ThyrionPaul Boon

Abstract

Recent evidence points at an important role of endogenous cell-damage induced pro-inflammatory molecules in the generation of epileptic seizures. Uric acid, under the form of monosodium urate crystals, has shown to have pro-inflammatory properties in the body, but less is known about its role in seizure generation. This study aimed to unravel the contribution of uric acid to seizure generation in a mouse model for acute limbic seizures. We measured extracellular levels of uric acid in the brain and modulated them using complementary pharmacological and genetic tools. Local extracellular uric acid levels increased three to four times during acute limbic seizures and peaked between 50 and 100 min after kainic acid infusion. Manipulating uric acid levels through administration of allopurinol or knock-out of urate oxidase significantly altered the number of generalized seizures, decreasing and increasing them by a twofold respectively. Taken together, our results consistently show that uric acid is released during limbic seizures and suggest that uric acid facilitates seizure generalization.

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Citations

Oct 9, 2019·Journal of Clinical Neurology·Il Han YooKi Joong Kim
Dec 11, 2019·Epilepsia Open·Robert D NassRainer Surges
Jul 20, 2018·Neurotoxicity Research·Dongxing WangXia Zhang

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