Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study

Circulation. Heart Failure
Kazuhide OginoWolfram Doehner

Abstract

Hyperuricemia is common in chronic heart failure (CHF), and it is a strong independent marker of prognosis. Upregulated xanthine oxidase (XO) activity and impaired renal excretion have been shown to account for increased serum uric acid (UA) levels in CHF. Therapeutic interventions with allopurinol to reduce UA levels by XO inhibition have been shown to be beneficial. Discussions are ongoing whether UA itself is actively involved or it is a mere marker of upregulated XO activity within CHF pathophysiology. Therefore, the aim of this study was to test the effect of lowering UA by uricosuric treatment without XO inhibition on hemodynamic and metabolic characteristics of CHF. Impaired renal excretion of UA was taken into account. Serum UA (SUA), urinary UA (uUA) excretion, and renal clearance test for UA (Cl(UA)) were measured in 82 patients with CHF. SUA was significantly increased compared with controls of similar age (control, 5.45+/-0.70 mg/dL; New York Heart Association I, 6.48+/-1.70 mg/dL; New York Heart Association II, 7.34+/-1.94 mg/dL; New York Heart Association III, 7.61+/-2.11 mg/dL; P<0.01). Patients with CHF showed lower uUA excretion and Cl(UA). On multivariate analysis, insulin, brain natriuretic peptide (P<0.01), ...Continue Reading

Associated Clinical Trials

References

Jul 1, 1979·British Journal of Clinical Pharmacology·M Hills, P Armitage
Dec 4, 1991·JAMA : the Journal of the American Medical Association·F FacchiniG M Reaven
Aug 1, 1997·Journal of the American College of Cardiology·J W SwanA J Coats
Sep 29, 1998·Metabolism: Clinical and Experimental·F LeyvaA J Coats
Jan 14, 1999·European Heart Journal·F LeyvaA J Coats
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Kimiyoshi IchidaTatsuo Hosoya
Sep 20, 2005·Journal of the American College of Cardiology·Wolfram DoehnerStefan D Anker
Jun 20, 2006·International Journal of Cardiology·Ewa A JankowskaPiotr Ponikowski
Jul 18, 2006·International Journal of Cardiology·Wolfram DoehnerStefan D Anker
Sep 6, 2006·Journal of Cardiac Failure·Horacio E CingolaniNéstor G Pérez
Jun 14, 2008·Journal of the American College of Cardiology·Joshua M HareUNKNOWN OPT-CHF Investigators
Nov 15, 2008·European Journal of Heart Failure·Wolfram DoehnerStefan D Anker

❮ Previous
Next ❯

Citations

Oct 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mehmet KanbayRichard J Johnson
Sep 10, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhide OginoChiaki Shigemasa
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Mehmet KanbayRichard J Johnson
Mar 13, 2014·Nature Reviews. Rheumatology·Frances ReesMichael Doherty
Aug 20, 2014·Nature Reviews. Rheumatology·Pascal RichetteThomas Bardin
May 16, 2012·Heart Failure Reviews·Marc Kaufman, Maya Guglin
Jan 1, 2013·Heart and Vessels·Yoichiro OtakiIsao Kubota
Apr 25, 2013·Current Medical Research and Opinion·E Agabiti-Rosei, G Grassi
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Sebastian E SattuiAngelo L Gaffo
Sep 22, 2012·Biochemical and Biophysical Research Communications·Hidetoshi TsudaYoshitaka Isaka
Jan 18, 2014·The Journal of Sexual Medicine·Yalcin SolakMehmet Kanbay
Feb 22, 2012·The American Journal of Medicine·Vijay LapsiaA Ahsan Ejaz
Oct 18, 2011·Seminars in Nephrology·Richard J JohnsonLaura Gabriela Sánchez-Lozada
Aug 25, 2011·International Journal of Cardiology·Shao-Yuan ChuangWen-Harn Pan
Jan 5, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S BaldasseroniUNKNOWN IN-CHF Investigators
Dec 26, 2015·European Journal of Internal Medicine·Mehmet KanbayRichard J Johnson
Mar 26, 2014·Annals of the Rheumatic Diseases·Maureen DubreuilHyon K Choi
May 17, 2012·Congestive Heart Failure·Eswar KrishnanBhavik J Pandya
Aug 13, 2013·European Journal of Heart Failure·He HuangJi Wang
Jul 6, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S-Y ChuangW-H Pan
Feb 14, 2012·The American Journal of Cardiology·Gjin NdrepepaAdnan Kastrati
Sep 21, 2015·International Journal of Cardiology·Maurizio VolterraniFranco Romeo
Sep 6, 2015·International Journal of Cardiology·Audrey H WuGerasimos Filippatos
Jul 25, 2015·Diabetes·Richard J JohnsonMiguel A Lanaspa
Apr 29, 2015·Diabetes·Ivonne SluijsUNKNOWN InterAct Consortium
Jan 8, 2014·Annals of the Rheumatic Diseases·L Grimaldi-BensoudaUNKNOWN PGRx MI Group
Jun 12, 2013·International Journal of Cardiology·Jochen SpringerWolfram Doehner
Sep 26, 2013·Diabetes·Richard J JohnsonMiguel A Lanaspa
Apr 20, 2017·Nutrients·Cristiana CalicetiArrigo F G Cicero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.