Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system

Journal of Hypertension
Dalila B CorryMichael L Tuck

Abstract

Plasma uric acid has been associated with hypertension in a variety of disorders, and has been shown to be predictive of hypertension. The mechanistic role of uric acid in the development of hypertension is not known however. We tested the hypothesis that uric acid stimulates vascular smooth muscle cell (VSMC) proliferation and oxidative stress by stimulating the vascular renin-angiotensin system (RAS). Rat VSMC were exposed to 0-300 micromol uric acid for 48 h. Uric acid (200 and 300 micromol) stimulated the proliferation of VSMC as measured by thymidine uptake. This effect was prevented by 10(-6) mol losartan or by 10(-6) mol captopril. Incubation of VSMC with uric acid for 48 h also increased angiotensinogen messenger RNA expression and intracellular concentrations of angiotensin II. These responses were also inhibited by losartan and captopril. Increased expression of angiotensinogen mRNA was also inhibited by co-incubation with PD 98059, a mitogen-activated protein (MAP) kinase inhibitor. Uric acid stimulated the production of hydrogen peroxide and 8-isoprostane in VSMC. These increases in oxidative stress indicators were significantly reduced by co-incubating the cells with captopril or losartan. Uric acid also decreased ...Continue Reading

References

Mar 10, 1979·British Medical Journal·L E Ramsay
Jun 1, 1978·Journal of the American Geriatrics Society·I SaitoE Kato
Dec 1, 1980·Annals of Internal Medicine·F H MesserliG G Aristimuno
Sep 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A I Sánchez-FructuosoA Barrientos
Jul 2, 1998·Archives of Biochemistry and Biophysics·M HoustonB A Freeman
Nov 21, 1998·Free Radical Biology & Medicine·V SchlotteK U Weithmann
Jul 27, 1999·Journal of Hypertension·J G Puig, L M Ruilope
Jun 28, 2001·Physiological Reviews·B C Berk
May 9, 2002·American Journal of Physiology. Renal Physiology·Marilda MazzaliRichard J Johnson
Aug 6, 2003·Hypertension·Daniel I Feig, Richard J Johnson
Feb 12, 2004·Kidney International·Aud HøieggenUNKNOWN LIFE Study Group
Oct 2, 2004·Kidney International·Todd S PerlsteinNaomi D L Fisher

❮ Previous
Next ❯

Citations

Jul 24, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Richard J JohnsonSteven A Benner
Mar 27, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elżbieta Kuroczycka-SaniutyczRobert Milewski
May 16, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justyna TomczakRobert Milewski
May 7, 2011·International Urology and Nephrology·Markus RiegerspergerDavid Goldsmith
Jul 4, 2012·International Urology and Nephrology·Ozkan GungorHuseyin Toz
May 5, 2006·Current Hypertension Reports·Dalila B Corry, Michael L Tuck
Apr 29, 2010·Current Hypertension Reports·Rodolfo Leão BorgesMarcelo Costa Batista
Sep 28, 2013·Current Hypertension Reports·Carmine Zoccali, Francesca Mallamaci
Oct 23, 2013·Asian Pacific Journal of Tropical Biomedicine·Bibek PoudelKanak Bahadur Raut
Mar 1, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryuichi KawamotoTetsuro Miki
Feb 12, 2010·Journal of Human Hypertension·I M PalmerH W Huisman
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Feb 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pietro CirilloRichard J Johnson
Oct 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wei ChenXueqing Yu
Oct 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mehmet KanbayRichard J Johnson
Jan 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iddo Z Ben-Dov, Jeremy D Kark
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Imed HelalGodela M Fick-Brosnahan
Apr 9, 2013·QJM : Monthly Journal of the Association of Physicians·A G StackH T Nguyen
Oct 11, 2011·Cardiology in Review·Anita KelkarWilliam H Frishman
Aug 6, 2009·Current Opinion in Nephrology and Hypertension·Daniel I Feig
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Laura G Sánchez-LozadaRichard J Johnson
Aug 22, 2009·American Journal of Nephrology·Carlos A RoncalRichard J Johnson
Jun 11, 2011·American Journal of Nephrology·Baris AfsarMehmet Kanbay
Jun 27, 2013·BMC Cardiovascular Disorders·Atila Alexandre TrapéAnderson Saranz Zago
Feb 2, 2013·Clinical and Translational Medicine·Mehdi A FiniRichard M Wright
Sep 4, 2009·Arthritis Research & Therapy·Angelo L GaffoKenneth G Saag
Jan 20, 2009·Endocrine Reviews·Richard J JohnsonTakahiko Nakagawa
Sep 10, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhide OginoChiaki Shigemasa
Dec 30, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Angelo L Gaffo, Kenneth G Saag
Dec 15, 2010·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Emily BoltonKaren Walker-Bone
Oct 5, 2010·The Journal of Rheumatology·Tuhina NeogiYuqing Zhang
Mar 16, 2011·Cardiology Research and Practice·Mário Raimundo, José António Lopes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.