Uric acid within the "normal" range predict 9-year cardiovascular mortality in older individuals. The InCHIANTI study

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Gloria BromboGiovanni Zuliani

Abstract

Increased uric acid levels correlate with cardiovascular disease and cardiovascular/overall mortality. To identify a uric acid threshold above which cardiovascular mortality rises, we studied the relationship between uric acid concentration and overall/cardiovascular mortality. We analyzed data from the InCHIANTI study, a cohort study of Italian community-dwelling people with 9 years of follow-up. We selected a sample of 947 individuals over 64 years of age, free from cardio-cerebrovascular disease and with available uric acid measurement at baseline. The sample was divided according to plasma uric acid tertiles. The Hazard ratio (HR) for mortality was calculated by multivariate Cox proportional hazard model. Mean age of participants was 75.3 ± 7.3 years; the mean value of uric acid was 5.1 ± 1.4 mg/dl. Over 9-years of follow-up, 342 (36.1%) participants died, 143 deaths (15.1%) were due to cardiovascular disease. Subjects with higher uric acid concentrations presented a higher cardiovascular mortality [II (4.6-5.5 mg/dl) vs I (1.8-4.5 mg/dl) tertile HR: 1.98, 95%C.I. 1.22-3.23; III (≥5.6 mg/dl) vs I tertile HR: 1.87, 95%C.I. 1.13-3.09]. We found a non-linear association between uric acid concentrations and cardiovascular morta...Continue Reading

Citations

Sep 12, 2020·Antioxidants·Maria Giulia BattelliLetizia Polito
Jul 23, 2020·Journal of Hypertension·Maria L MuiesanUNKNOWN from the Working Group on Uric Acid, Cardiovascular Risk of the Italian Society of Hypertension
Nov 24, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ruihua LiuXiao Yang
Nov 28, 2020·Frontiers in Cardiovascular Medicine·Ziliang SongXu Liu

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