PMID: 7028116Aug 20, 1981Paper

Uridine and uracil transport in Escherichia coli and transport-deficient mutants

Biochimica Et Biophysica Acta
S Roy-Burman, D W Visser

Abstract

Mutants of Escherichia coli K-12 which are defective in components of transport systems for uracil and uridine were isolated and utilized to characterize the transport mechanism of uracil and uridine. Mutant U-, isolated from a culture of the parent strain, is resistant to 5-fluorouracil and is deficient in the uracil transport system. Mutant UR-, isolated from a culture of the parent strain, is resistant to a low concentration of showdomycin and lacks the capacity to transport intact uridine. Mutant U-UR- isolated from a culture of mutant U-, is resistant to a low concentration of showdomycin and is defective in both uracil and intact uridine transport processes. Mutant UR-R- was isolated from a culture of mutant UR-, and is resistant to a high concentration of showdomycin. This mutant is defective for transport of intact uridine and addition lacks the transport system for the ribose moiety of uridine. Characteristics of uracil and uridine transport in parent and mutant cells demonstrate the existence of specific transport processes for uracil, intact uridine and the uracil and ribose moieties of uridine. Mutants U- and UR-, which are defective for uracil transport, lack uracil phosphoribosyltransferase activity and retain a s...Continue Reading

References

Nov 15, 1977·The Biochemical Journal·K Burton
Nov 15, 1975·European Journal of Biochemistry·B Mygind, Munch-Petersen
Dec 1, 1976·Journal of Cellular Physiology·A Munch-Petersen, B Mygind
Feb 27, 1974·Biochemical and Biophysical Research Communications·J Doskocil
Jul 18, 1973·Biochimica Et Biophysica Acta·Y Komatsu, K Tanaka
Mar 1, 1974·CRC Critical Reviews in Biochemistry·J Hochstadt
Aug 9, 1973·Biochimica Et Biophysica Acta·P J von DippeD W Visser
Dec 13, 1973·Biochimica Et Biophysica Acta·Y Komatsu
Jul 1, 1950·Journal of Bacteriology·B D DAVIS, E S MINGIOLI
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·K R DarnallR K Robins

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Citations

Jun 3, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H C Berg
Sep 1, 2008·EcoSal Plus·Kaj Frank JensenMartin WillemoËs

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