PMID: 6162914Mar 1, 1981Paper

Uridine metabolism in the goldfish retina during optic nerve regeneration: whole retina studies

Journal of Neurochemistry
L A DokasB W Agranoff

Abstract

Accumulation of radioactivity from [3H]uridine in incubations of whole goldfish retinas is increased in the ipsilateral retina during a period of regeneration that follows unilateral optic nerve crush. Brief incubations to investigate the nature of enhanced labeling of the acid-soluble fraction showed a peak uptake 4 days following crush, with a gradual decrease to control levels by 21 days following crush. That nucleoside uptake may not mediate the effect is supported by the observation that the rate of uptake of 5'-deoxyadenosine, a nonmetabolizable nucleoside analog, is the same in post-crush (PC) and normal (N) retinal incubations. Following brief incubations of PC and N retinas with [3H]uridine, there is enhanced labeling in PC retinas relative to N retinas of recovered UMP, UDP, UTP, and uridine nucleotide sugars, whereas recovery of labeled uridine itself is slightly decreased. The results suggest that the increased accumulation of radioactivity in PC retinas following incubation with uridine reflects an increase in the activities of retinal uridine kinase and uridine nucleotide kinases.

References

Jul 1, 1978·Journal of Neurochemistry·H R BurrellB W Agranoff
Jun 2, 1977·Nature·E RozengurtN M Wigglesworth
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A M Heacock, B W Agranoff
Sep 1, 1975·Experimental Neurology·B Grafstein
May 1, 1974·Journal of Neurochemistry·D S DunlopA Lajtha
Jul 1, 1974·Pediatric Research·R L LevineN Kretchmer
Apr 1, 1973·Canadian Journal of Biochemistry·G Krystal, P G Scholefield
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Sep 26, 1966·Biochimica Et Biophysica Acta·M Levine, W D Stein
Mar 1, 1980·Journal of Neurochemistry·C J LangfordL Austin

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Citations

Jun 1, 1982·Neurochemical Research·A M Heacock, B W Agranoff
Jan 1, 1990·Neuroscience Research. Supplement : the Official Journal of the Japan Neuroscience Society·Y FukudaK Morigiwa
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·R P BallesteroB W Agranoff
Jan 1, 1987·CRC Critical Reviews in Biochemistry·M Schwartz
Jun 1, 1983·Experimental Neurology·P Singer, S Mehler

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