Uridine reduces rotation induced by L-dopa and methamphetamine in 6-OHDA-treated rats

Pharmacology, Biochemistry, and Behavior
C S MyersG C Wagner

Abstract

The pyrimidine nucleoside uridine may reduce side effects associated with antipsychotic medication by interacting with dopamine or GABA neurotransmission. Male Sprague-Dawley rats were used to investigate coadministration of uridine with agents that alter food intake (amphetamine, haloperidol, and chlordiazepoxide) and locomotor activity (methamphetamine and L-dopa). Results indicated that chronic uridine [32.0 mg/kg, intraperitoneally (IP)] alone did not alter milk intake or reduction of milk intake induced by amphetamine (dose range 0.5-2.0 mg/kg, IP) or haloperidol (0.125-1.0 mg/kg, IP), nor did it alter the biphasic response induced by chlordiazepoxide (5.0-40.0 mg/kg, IP). However, uridine-treated animals with unilateral striatal lesions exhibited no rotational behavior in the absence of drug challenge, but showed decreased rotation induced by the dopamine agonist, L-dopa (50.0-200.0 mg/kg, IP) compared with controls. In addition, uridine-treated rats exhibited reduced rotation after repeated injections of methamphetamine (4.0 mg/kg, IP) in contrast to increasingly greater rotation observed in control animals. These results are further evidence that chronic uridine may alter drug-induced dopaminergic activity without exert...Continue Reading

References

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Oct 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·C S MyersG C Wagner

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Citations

Jun 4, 1999·Trends in Pharmacological Sciences·G P Connolly, J A Duley
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·T PageW L Nyhan
Jul 21, 2004·Neurobiology of Disease·A SléziaG Juhász
Jul 17, 2010·Annals of the New York Academy of Sciences·Shruti V Kabadi, Timothy J Maher
Aug 5, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ping LiuJingyu Yang
Mar 10, 2017·Nutritional Neuroscience·Paula Perez-PardoAletta D Kraneveld
Jun 14, 2006·Brain Research Reviews·Mehmet Cansev

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