Urinary β2-Microglobulin Is a Good Indicator of Proximal Tubule Injury: A Correlative Study with Renal Biopsies

Journal of Biomarkers
Xu ZengPing L Zhang

Abstract

Objective. After filtration through glomeruli, β2-microglobulin is reabsorbed in proximal tubules. Increased urinary β2-microglobulin indicates proximal tubule injury and measurement of β2-microglobulin in urine is useful to determine the source of renal injury. Kidney injury molecule-1 (KIM-1) has been characterized as a selective proximal tubule injury marker. This study was designed to evaluate the correlation of urinary β2-microglobulin concentration and KIM-1 expression as evidence of proximal tubule injury. Methods. Between 2009 and 2012, 46 patients with urine β2-microglobulin (RenalVysion) had follow-up kidney biopsy. Diagnoses included glomerular and tubule-interstitial disease. Immunohistochemical staining for KIM-1 was performed and the intensity was graded from 0 to 3+. Linear regression analysis was applied to correlate the values of urinary β2-microglobulin and KIM-1 staining scores. P < 0.05 was considered statistically significant. Results. Thirty patients had elevated urinary β2-microglobulin. KIM-1 staining was positive in 35 kidney biopsies. There was a significant correlation between urinary β2-microglobulin and KIM-1 staining (P < 0.05). Sensitivity was 86.6%, specificity was 43.7%, positive predictive valu...Continue Reading

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Citations

Aug 2, 2019·International Journal of Molecular Sciences·Justyna WajdaBeata Kuśnierz-Cabala
Jul 1, 2017·Frontiers in Medicine·Christos P ArgyropoulosAntonios H Tzamaloukas
May 31, 2017·Journal of Clinical Pharmacy and Therapeutics·L ShahJ J Zaritsky
Sep 26, 2020·Medicina·Rόisín C ThomasCordula M Stover
Mar 20, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Thilini Madushanka WijerathnaNicholas Alan Buckley
Nov 7, 2017·Expert Review of Proteomics·Arjun Chakraborty, Minnie Sarwal
Jan 3, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shimrit Tzvi-BehrEfrat Ben Shalom
Feb 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Asako HayashiTakayuki Okamoto
Nov 26, 2021·Frontiers in Genetics·Melanie A GovenderMichèle Ramsay

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

RenalVysion

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