Urinary 3-methylhistidine excretion: association with total body skeletal muscle mass by computerized axial tomography

JPEN. Journal of Parenteral and Enteral Nutrition
Z WangS B Heymsfield

Abstract

The urinary excretion of endogenous 3-methylhistidine (3-MH) has been proposed as a predictor of skeletal muscle mass (SM). In this study, we report the relationship between 24-hour urinary 3-MH excretion and SM. Total body SM was measured by multiscan computerized axial tomography (CT) in a sample of 10 healthy adult men who followed a meat-free diet for 7 days. 3-MH was measured during the last 3 days of the meat-free diet protocol on consecutive 24-hour urine collections. The 3-MH excretion was 216.3 +/- 44.7 mumol/d (mean +/- SD) and was found well associated with SM (in kilograms), SM = 0.0887 x 3-MH + 11.8; r = .88, p < .001. Compared with CT, the previous 3-MH-SM prediction equation suggested by Lukaski et al underestimated SM by an average of 8.9 kg in the 10 healthy men. This difference was caused by the Burkinshaw-Cohn neutron activation model, which underestimated SM and was used as the reference in the Lukaski method. Twenty-four-hour urinary 3-MH excretion can be applied for estimating SM in healthy adult men on a meat-free diet.

References

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Citations

Dec 18, 2009·Analytical and Bioanalytical Chemistry·Jingjing XuZhong Chen
Jul 10, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Lars Holm, Michael Kjaer
Jan 1, 1997·Annual Review of Nutrition·S B HeymsfieldR Ross
Aug 15, 2013·Journal of Cachexia, Sarcopenia and Muscle·Anders NedergaardCharlotte Suetta
Apr 9, 2015·The Proceedings of the Nutrition Society·Steven B HeymsfieldJolene Zheng
Aug 25, 2015·Neuromuscular Disorders : NMD·Takahiro MotokiMasayuki Sasaki
Jan 23, 2015·PloS One·Hiroshi FukushimaFumitaka Koga
Apr 23, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Taku NakagawaMasafumi Matsuo
Dec 6, 2011·The Science of the Total Environment·Christian G Daughton
Jun 19, 2018·Current Opinion in Supportive and Palliative Care·Levent ÖzçakarDinesh Kumbhare
Feb 13, 2008·Scandinavian Journal of Medicine & Science in Sports·M HansenH Langberg
Aug 26, 2003·The American Journal of Clinical Nutrition·Stéphanie ChevalierJosé A Morais
Dec 25, 2002·The American Journal of Clinical Nutrition·ZiMian WangSteven B Heymsfield

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