Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Rafal RozalskiRyszard Olinski

Abstract

Oxidative stress linked with chronic inflammation is associated with etiology of the colorectal cancer. To assess the diagnostic utility of urinary excretion of oxidatively modified DNA bases/nucleoside: 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 5-hydroxymethyluracil (5-hmUra). Seventy-two healthy controls, 15 patients with adenomas and 56 colorectal cancer patients were recruited. The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for all markers tested separately was <0.7. The combination of these modifications showed better diagnostic power (AUC = 0.778 for 8-oxoGua + 8-oxodG)/5hmUra ratio). Urinary DNA modifications may reflect the oxidative stress/chronic inflammation in colorectal cancer but diagnostic performance for early-detection is moderate.

References

Sep 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C DecarrozJ Cadet
Sep 22, 1999·Chemical Research in Toxicology·J L RavanatJ Cadet
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·V Rusmintratip, L C Sowers
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·R TangL L Hsieh
May 7, 2002·EMBO Reports·Moran BenharAlexander Levitzki
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 26, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J DuffyO Topolcan
Nov 26, 2003·Mutation Research·Ryszard OlinskiKarol Bialkowski
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emanuela FlaminiDino Amadori
Jun 11, 2008·Cancer Causes & Control : CCC·Michael GoodmanJack Mandel
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Elaine Y L LeungDonald C McMillan
Sep 14, 2010·Best Practice & Research. Clinical Gastroenterology·Michael Bretthauer
Nov 16, 2011·Nature Reviews. Genetics·Miguel R BrancoWolf Reik
Jan 27, 2012·Free Radical Research·Miral Dizdaroglu, Pawel Jaruga
Jan 18, 2014·Molecular Biology Reports·M Cavia-SaizC García Girón
Dec 5, 2014·World Journal of Gastroenterology : WJG·Wen-Jun JinPei-Wei Li

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Citations

Apr 2, 2019·Journal of Occupational and Environmental Hygiene·M Ariel Geer WallaceGavin P Horn
Dec 2, 2017·Oncotarget·Weiqiang FeiXiaotong Hu
Jul 19, 2020·International Journal of Molecular Sciences·Györgyi FerencLajos Kovács
Mar 15, 2020·Scientific Reports·Priyanka BhadwalNavneet Agnihotri
Feb 28, 2020·World Journal of Gastrointestinal Oncology·Alexandre Loktionov
May 22, 2018·Gastroenterology Report·Yu ZhenHu Zhang
Sep 30, 2019·Free Radical Biology & Medicine·Emil List LarsenHenrik Enghusen Poulsen

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