Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults.

American Journal of Epidemiology
Xiang GaoKatherine L Tucker

Abstract

DNA oxidative stress has been suggested as an important pathogenic mechanism in cognitive impairment and dementia. With baseline data collected from 2004 to 2008, the authors examined whether urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of global DNA oxidation, was associated with cognitive function in a sample of 1,003 Puerto Rican adults, aged 45-75 years, living in Boston, Massachusetts, and the surrounding area. Cognitive function was measured by using a battery of 7 tests: the Mini-Mental State Examination, word list learning, digit span, clock drawing and figure copying, Stroop, and verbal fluency tests. The primary outcome was a global cognitive score, averaging standardized scores across all cognitive tests. A higher 8-OHdG concentration was significantly associated with lower global cognitive scores, after adjustment for age, education, status of the gene for apolipoprotein E (APOE), and other covariates (P(trend) = 0.01). The difference in the global score, comparing participants in the 2 extreme 8-OHdG quartiles, was -0.11 (95% confidence interval: -0.20, -0.02), which was equivalent to accelerating cognitive aging by about 4 years, as observed in this population. Prospective studies are needed to elucida...Continue Reading

Associated Clinical Trials

Nov 1, 2010·Katherine Tucker

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Citations

Aug 11, 2012·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Guang-xia ShiLin-peng Wang
Nov 1, 2011·Free Radical Research·Pavel Rossner, Radim J Sram
Mar 8, 2019·Nutritional Neuroscience·Natalia PalaciosKatherine L Tucker
Apr 6, 2019·The Journal of Nutrition·Natalia PalaciosKatherine L Tucker

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