PMID: 18203092Jan 19, 2008Paper

Urinary 8-hydroxydeoxyguanosine levels in diabetic retinopathy patients

European Journal of Ophthalmology
Q Y DongL Sun

Abstract

Involvement of oxidative stress in the pathogenesis of diabetic microvascular complications has been proposed. Recently, 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. This study was undertaken to investigate whether the urinary levels of 8-OHdG are altered in patients with type 2 diabetes. The authors also attempted to analyze the relationship between 8-OHdG levels and other clinical parameters of patients with diabetes, especially the relationship between oxidative DNA damage and the severity of the retinal lesions in patients with diabetic retinopathy. The authors studied 60 patients with type 2 diabetes and compared them with 35 nondiabetic control subjects. Urinary 8-OHdG concentrations were assayed using competitive enzymelinked immunosorbent assay. The patients with type 2 diabetes had significantly higher concentrations of 8-OHdG in their urine than the control subjects (19.6+/-6.7 vs 11.9+/-4.9 ng/mgCr; p<0.05). The authors could not find any correlation between urinary 8-OHdG levels and age, duration of diabetes, or serum lipids. However, HbA1c values were significantly correlated with 8-OHdG values. Among the patients with diabetes, th...Continue Reading

References

Jul 1, 1992·Diabetes Care·M I HarrisM W Knuiman
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C G FragaB N Ames
Feb 17, 1996·Lancet·P DandonaT Nicotera
Mar 1, 1996·Diabetes Care·D GiuglianoG Paolisso
Jul 29, 1998·Free Radical Biology & Medicine·I GrattaglianoE Altomare
Jul 10, 2001·Life Sciences·N OmataM Mayumi
May 23, 2002·European Journal of Ophthalmology·A J AugustinU Schmidt-Erfurth
Jun 8, 2002·Nephron·Masao KanauchiToshio Hashimoto
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chiuan Chian ChiouJames T Wu
Jul 21, 2007·Experimental Diabetes Research·Renu A Kowluru, Pooi-See Chan

❮ Previous
Next ❯

Citations

Aug 27, 2009·Acta Ophthalmologica·Orhan AtesIlknur A Salman
Nov 8, 2014·The Journal of Craniofacial Surgery·Ozgur YorukEbubekir Bakan
May 16, 2020·Journal of Ophthalmology·Altaf A KondkarSaleh A Al-Obeidan
May 30, 2020·International Journal of Molecular Sciences·Melanie GrailleNancy B Hopf
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Dec 6, 2017·Journal of Diabetes Research·Sonia Sifuentes-FrancoAlejandra Guillermina Miranda-Díaz
Sep 27, 2018·Oxidative Medicine and Cellular Longevity·Meng-Yu WuChia-Jung Li
Feb 6, 2020·Antioxidants & Redox Signaling·Sofia UrnerKarin Jandeleit-Dahm
Dec 10, 2019·Archives of Physiology and Biochemistry·Agnieszka Jura-PółtorakKrystyna Olczyk
Jan 6, 2009·European Journal of Ophthalmology·O AtesO Baykal
Feb 11, 2009·Free Radical Research·Noriko SakanoKeiki Ogino
Nov 1, 2011·Free Radical Research·Pavel Rossner, Radim J Sram
Mar 25, 2016·The Journal of International Medical Research·Xiaozhen YeHong Du
Jan 22, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Michiaki MiyamotoNobuyuki Taniguchi
Aug 23, 2020·Journal of Clinical Medicine·Alessandro GraziosiDiego Gazzolo
Oct 9, 2020·Yeungnam University Journal of Medicine·Soyoung Park, So-Young Park
Jun 20, 2020·ACS Applied Materials & Interfaces·Sanjida YeasminBo Liedberg
Jul 16, 2011·The American Journal of the Medical Sciences·Tsukasa NakamuraHikaru Koide
Aug 9, 2011·Free Radical Biology & Medicine·Kasper BroedbaekHenrik E Poulsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.