Urinary aflatoxin exposure monitoring in rural and semi-urban populations in Ogun state, Nigeria

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Chibundu N EzekielAdeyemi Dada

Abstract

Aflatoxins are a major class of fungal toxins that have food safety importance due to their economic and health impacts. This pilot aflatoxin exposure biomonitoring study on 84 individuals was conducted in a rural (Ilumafon) and a semi-urban community (Ilishan Remo) of Ogun state, Nigeria, to compare aflatoxin exposures among the two population cohorts. First morning urine samples were obtained from the participants, and the urinary aflatoxin M1 (AFM1) levels were measured by a quantitative Helica Biosystems Inc. ELISA kit assay. About 99% (83 out of 84) of the urine samples had detectable AFM1 levels in the range of 0.06 to 0.51 ng mL-1 (median: 0.27 ng mL-1). The mean urinary AFM1 levels were significantly (p = 0.001) higher in the semi-urban population (0.31 ± 0.09 ng mL-1) compared to the rural population (0.24 ± 0.07 ng mL-1). There were, however, no significant differences in mean urinary AFM1 levels of males and females, and among children, adolescents and adults. This study indicates high aflatoxin exposure to the extent of public health concerns in the studied populations. Thus, more efforts are required for aflatoxin exposure monitoring and control in high-risk regions.

References

Nov 19, 2002·Mutagenesis·C P Wild, P C Turner
Feb 8, 2003·Environmental Health Perspectives·Paul C TurnerChristopher P Wild
Nov 9, 2004·The American Journal of Clinical Nutrition·Jonathan H WilliamsDeepak Aggarwal
Dec 7, 2005·Environmental Health Perspectives·Lauren LewisUNKNOWN Kenya Aflatoxicosis Investigation Group
Feb 20, 2007·Applied and Environmental Microbiology·Claudia ProbstPeter J Cotty
Jun 20, 2007·International Journal of Epidemiology·Paul C TurnerChristopher P Wild
Oct 9, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nektaria PolychronakiPaul C Turner
Jan 28, 2009·World Journal of Pediatrics : WJP·Nilamadhab Kar
Jun 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Josep RubertCarla Soler
Jun 2, 2012·Nutrition Research Reviews·Paul C TurnerJames Pestka
Mar 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Oloyede AdejumoAlberto Ritieni
May 15, 2013·Environment International·Emmanuel Njumbe EdiageSarah De Saeger
Jun 19, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ellen E YardShahnaaz K Sharif
Oct 17, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wilfred A AbiaPaul F Moundipa
Mar 4, 2014·Environment International·Chibundu N EzekielRanajit Bandyopadhyay
May 2, 2014·Food Additives & Contaminants. Part B, Surveillance·O F KayodeC R B Oguntona
Oct 1, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Benedikt WarthRudolf Krska
Oct 25, 2014·Annals of Nutrition & Metabolism·Martani J Lombard
Sep 24, 2015·Archives of Toxicology·Nurshad AliGisela H Degen
Oct 9, 2015·The New England Journal of Medicine·Béatrice Lauby-SecretanKurt Straif
Dec 24, 2015·Frontiers in Microbiology·Chiamaka A OkekeRudolf Krska
May 6, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jeremy R SchwartzbordDan L Brown
Jun 15, 2016·Chemical Research in Toxicology·Benedikt WarthDoris Marko
Aug 21, 2016·International Journal of Food Microbiology·Chibundu N EzekielRudolf Krska
Dec 5, 2016·International Journal of Hygiene and Environmental Health·Nurshad AliGisela H Degen
Jan 25, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gaoyun ChenMichael N Routledge
Apr 6, 2017·International Journal of Food Microbiology·Oluwawapelumi A OyedeleRudolf Krska
Jul 4, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Abebe AyelignSarah De Saeger
Aug 12, 2017·Critical Reviews in Food Science and Nutrition·J M MisihairabgwiR Krska
Nov 28, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amy McMillanMark W Sumarah
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Chibundu N EzekielRudolf Krska

❮ Previous
Next ❯

Citations

Aug 11, 2020·Toxicon : Official Journal of the International Society on Toxinology·F N AhmadN Mohd Esa
Dec 22, 2021·Toxicology Mechanisms and Methods·Weiya CaoDongli Cao

❮ Previous
Next ❯

Methods Mentioned

BETA
AFM
Enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.