Urinary Albumin Levels Predict Development of Acute Kidney Injury After Pediatric Cardiac Surgery: A Prospective Observational Study

Journal of Cardiothoracic and Vascular Anesthesia
Kentaro SugimotoShunji Sano

Abstract

Mortality and morbidity of acute kidney injury (AKI) after cardiac surgery still remain high. The authors undertook the present study to evaluate the utility of early postoperative urinary albumin (uAlb) as a diagnostic marker for predicting occurrence of AKI and its severity in pediatric patients undergoing cardiac surgery. A prospective observational study. A single-institution university hospital. All patients<18 years of age who underwent repair of congenital heart disease with cardiopulmonary bypass between July 2010 and July 2012 were included in the study. Neonates age<1 month were excluded from the study population. The association between uAlb and occurrence of AKI within 3 days after admission to the intensive care unit was investigated. Criteria from pediatric-modified Risk Injury Failure Loss and End-stage kidney disease (pRIFLE) were used to determine the occurrence of AKI. The value of uAlb was measured at intensive care unit admission immediately after cardiac surgery in all participants from whom a 5-mL urine sample was obtained. Of 376 patients, AKI assessed by pRIFLE was identified in 243 (64.6%): 172 for risk (R; 45.7%), 44 for injury (I; 11.7%), and 27 for failure (F; 7.2%). One hundred thirty-three patients...Continue Reading

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Citations

Jul 12, 2018·Acta Anaesthesiologica Scandinavica·Ji-Hyun LeeJin-Tae Kim
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Feb 14, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Muhammad FaisalMohammed A Mohammed
Jul 28, 2019·BioMed Research International·Binbin WuYi Yang

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