Urinary and genital infections in patients with diabetes: How to diagnose and how to treat

Diabetes & Metabolism
P Njomnang SohB Bouhanick

Abstract

Diabetes is a predisposing factor for urinary tract and genital infections in both women and men. Sodium-glucose cotransporter-2 (SGLT2) inhibitors constitute a novel therapeutic class indicated for type 2 diabetes (T2D) patients, and are already on the market in a few countries in Europe. They decrease glycaemia mainly by enhancing glucose excretion in urine by reducing renal glucose reabsorption via the action of SGLT2 in the kidneys. In general, they are well tolerated, but their mode of action results in specific side effects as well as an increased risk of genital (vulvovaginitis and balanitis) and urinary tract infections, for which T2D patients are already at high risk, reported within the first 6 months of treatment. Usually these infectious events are successfully treated with standard therapies, but diabetologists are not accustomed to dealing with them. The aim of this review is to describe the different types of lower urinary tract and genital infections, and the treatment strategies currently available for patients with diabetes.

References

Jul 28, 1999·JAMA : the Journal of the American Medical Association·J N KriegerJ C Nickel
Feb 8, 2002·The Journal of Urology·Mary McNaughton CollinsIchiro Kawachi
Nov 15, 2002·The New England Journal of Medicine·Vincent T Andriole
May 17, 2003·Fertility and Sterility·Ashok AgarwalMohamed A Bedaiwy
Aug 27, 2004·The New England Journal of Medicine·Jack D SobelTeng-Chiao Chu
Aug 31, 2004·BMJ : British Medical Journal·Marie PirottaSuzanne Garland
Nov 2, 2004·Obstetrics and Gynecology·Richard H BeigiSharon L Hillier
Jun 23, 2005·International Journal of Antimicrobial Agents·F M E WagenlehnerK G Naber
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Albert John Phillips
Jun 23, 2006·The Journal of Antimicrobial Chemotherapy·Matthew E FalagasStavros Athanasiou
Aug 19, 2006·Scandinavian Journal of Urology and Nephrology·Alberto BudíaJ Fernando Jiménez Cruz
Jun 15, 2007·Lancet·Jack D Sobel
Aug 22, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·G G G DondersS S Witkin
Apr 9, 2010·Clinical Microbiology Reviews·Jacqueline M Achkar, Bettina C Fries
Nov 6, 2010·Gynecologic and Obstetric Investigation·Gianna Tempera, Pio Maria Furneri
Jul 22, 2011·Journal of Women's Health·Christos IavazzoMatthew E Falagas
Aug 20, 2011·Obstetrical & Gynecological Survey·Ioannis Mylonas, Florian Bergauer
Sep 24, 2011·Journal of Clinical Microbiology·Jane R SchwebkeCharlotte A Gaydos
May 25, 2012·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Daniel Engeler
Jul 31, 2012·Journal of Diabetes and Its Complications·Ishan HirjiAndres Gomez-Caminero
Feb 28, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G S TansarliM E Falagas
May 31, 2013·BMJ : British Medical Journal·Kalpana Gupta, Barbara W Trautner
Jan 7, 2014·Seminars in Reproductive Medicine·Harsha SharmaJames H Segars
Feb 11, 2014·The Journal of Infectious Diseases·Jane R SchwebkeWilliam E Josey
Feb 18, 2014·Diabetes Research and Clinical Practice·Suzanne GeerlingsShamik Parikh
Mar 4, 2014·Expert Opinion on Pharmacotherapy·Gilbert G G DondersDace Rezeberga
Feb 28, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Fernando Tadeu Andrade-Rocha

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Citations

Oct 19, 2017·Postgraduate Medicine·Sebastian Filippas-NtekouanMoses S Elisaf
Sep 19, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hiroshige MikamoTsutomu Tomita

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