Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients

Journal of Pharmaceutical and Biomedical Analysis
Álvaro Fernández-OchoaAntonio Segura-Carretero

Abstract

Systemic Sclerosis (SSc) is a chronic autoimmune disease whose origin and pathogenesis are not yet well known. Recent studies are allowing a better definition of the disease. However, few studies have been performed based on metabolomics. In this way, this study aims to find altered metabolites in SSc patients in order to improve their diagnosis, prognosis and treatment. For that, 59 SSc patients and 28 healthy volunteers participated in this study. Urine and plasma samples were analysed by a fingerprinting metabolomic approach based on HPLC-ESI-QTOF-MS. We observed larger differences in urine than plasma metabolites. The main deregulated metabolic families in urine were acylcarnitines, acylglycines and metabolites derived from amino acids, specifically from proline, histidine and glutamine. These results indicate perturbations in fatty acid beta oxidation and amino acid pathways in scleroderma patients. On the other hand, the main plasma biomarker candidate was 2-arachidonoylglycerol, which is involved in the endocannabinoid system with potential implications in the induction and propagation of systemic sclerosis and autoimmunity.

Citations

May 6, 2019·Expert Opinion on Therapeutic Targets·Thomas BerteroStephen Y Chan
Jun 21, 2020·Annals of the Rheumatic Diseases·Lorenzo BerettaUNKNOWN PRECISESADS Flow Cytometry study group
Sep 23, 2020·Current Rheumatology Reports·Hanlin YinQingran Yan
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Fanni TóthAttila Oláh
Jan 16, 2020·Metabolites·Álvaro Fernández-OchoaAntonio Segura-Carretero
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Rui ChangPeizeng Yang
May 29, 2020·Journal of Proteome Research·Álvaro Fernández-OchoaAntonio Segura-Carretero
Sep 10, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Fuchang LiChunyang Wang
Sep 18, 2021·Current Opinion in Rheumatology·Neža BrezovecKatja Lakota

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