Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus

Kidney & Blood Pressure Research
Yaoxian LiangYue Wang

Abstract

Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate UACE2 levels in type 2 diabetic patients with various degrees of albuminuria and its associations with metabolic parameters. The effect of RAS inhibitors on UACE2 excretion was also assessed. A total of 132 type 2 diabetic patients with different degrees of albuminuria and 34 healthy volunteers were studied. UACE2 levels and activity were measured. Compared to healthy controls, UACE2 to creatinine (UACE2/Cr) levels were significantly increased in both albuminuric and non-albuminuric diabetic patients. UACE2/Cr levels were much higher in hypertensive diabetic patients compared with their normotensive counterparts and treatment with RAS inhibitors markedly attenuated the augmentation. Furthermore, UACE2/Cr was positively correlated with fasting blood glucose, hemoglobin A1C (HbA1C), triglyceride, and total cholesterol. In multiple regression analysis, UACE2/Cr was independently predicted by HbA1C and RAS inhibitors treatment. UACE2...Continue Reading

Citations

Jun 18, 2016·International Urology and Nephrology·Ciorba Pop MarianaKacso Ina Maria
Sep 21, 2017·Current Hypertension Reports·Silas CulverHelmy M Siragy
Mar 22, 2018·American Journal of Physiology. Renal Physiology·Sridevi GuttaKhalid M Elased
May 30, 2019·American Journal of Physiology. Renal Physiology·Vanesa PalauMarta Riera
Apr 23, 2020·Clinical Pharmacology and Therapeutics·Krishna Sriram, Paul A Insel
Jun 27, 2020·Diabetes/metabolism Research and Reviews·Yue ZhouYangang Wang
Jul 31, 2020·Molecular Systems Biology·Sanju SinhaEytan Ruppin
Dec 29, 2018·Biochemia Medica·Akankwasa GilbertXiaosong Qin
Mar 12, 2021·Frontiers in Physiology·Simon B GressensEmmanuelle Vidal-Petiot
Apr 17, 2021·International Journal of Endocrinology·Gerui LiJinping Lu

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