Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study

Clinical Journal of the American Society of Nephrology : CJASN
Meredith C FosterCKD Biomarkers Consortium

Abstract

Liver fatty acid binding protein (L-FABP), kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glucosaminidase (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) are urinary markers of tubular injury that may also be markers of chronic kidney damage. We evaluated the association of these markers with incident ESRD in a community-based sample from the Atherosclerosis Risk in Communities Study. This was a matched case-control study of 135 patients with ESRD and 186 controls who were matched on sex, race, kidney function, and diabetes status at baseline (Atherosclerosis Risk in Communities Study visit 4, 1996-1998). Urinary KIM-1 indexed to creatinine (Cr), NAG/Cr, NGAL/Cr, and L-FABP/Cr were measured in stored spot urine samples from the baseline examination. Associations of KIM-1/Cr, NAG/Cr, and NGAL/Cr with patients with incident ESRD through 2008 were modeled continuously and categorically (quartiles) using conditional logistic regression. L-FABP/Cr was modeled only categorically because of a large number of measurements below the lower limit of detection for the assay (2.4 ng/ml). No significant associations were observed for NAG/Cr, NGAL/Cr, or L-FABP/Cr with ESRD. Those in the highest category for KIM-1/Cr had a higher...Continue Reading

References

Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Nov 26, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lori D BashJosef Coresh
Jun 18, 2010·Kidney International·Sushrut S WaikarJoseph V Bonventre
Feb 7, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brad C AstorJosef Coresh
May 1, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nrupen A BhavsarBrad C Astor
Jul 4, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Carmen A PeraltaMichael G Shlipak
Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Edward R SmithStephen G Holt
Jan 25, 2013·Kidney International·Kathleen D LiuUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) study investigators
Feb 5, 2013·Diabetes Care·Nicolae M PanduruUNKNOWN FinnDiane Study Group
Jun 15, 2013·Journal of the American Society of Nephrology : JASN·Meredith C FosterW H Linda Kao
Nov 5, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wei YangUNKNOWN CRIC Study Investigators
Oct 16, 2014·Diabetologia·Gudeta D FufaaUNKNOWN Chronic Kidney Disease Biomarkers Consortium Investigators
Nov 9, 2014·Clinical Journal of the American Society of Nephrology : CJASN·F Perry WilsonUNKNOWN CRIC Study Investigators
Mar 17, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Casey M RebholzMorgan E Grams

❮ Previous
Next ❯

Citations

Feb 13, 2016·Journal of Endourology·Clinton D Bahler, Chandru P Sundaram
Jul 19, 2016·Progress in Pediatric Cardiology·Prasad Devarajan, John Lynn Jefferies
Jun 9, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sushrut S WaikarUNKNOWN Chronic Kidney Disease Biomarkers Consortium Investigators
Mar 7, 2017·Nature Reviews. Nephrology·Berthold Hocher, Jerzy Adamski
Mar 2, 2017·Scandinavian Journal of Medicine & Science in Sports·K KosakiS Maeda
Jul 27, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Dinah S KhatirNiels H Buus
Feb 12, 2019·Annual Review of Physiology·William R Zhang, Chirag R Parikh
Jan 18, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Katherine G GarloDavid M Charytan
Mar 4, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Meyeon ParkUNKNOWN CKD Biomarkers Consortium
Dec 25, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Jose Manuel Monroy Trujillo, Derek Michael Fine
May 6, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mustafa Arici
Oct 18, 2016·Current Opinion in Nephrology and Hypertension·Lekha TummalapalliSteven G Coca
Dec 1, 2018·Journal of Nephrology·Tobias FeldreichJohan Ärnlöv
Sep 2, 2020·The Journal of Clinical Hypertension·Keiko HosohataEtsuko Kumagai
Mar 1, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Rakesh MalhotraMichael G Shlipak
Jun 28, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Insa M SchmidtUNKNOWN Chronic Kidney Disease Biomarkers Consortium and the CRIC Study Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.