Urinary biomarkers of kidney tubule injury, risk of acute kidney injury, and mortality in patients with acute ischaemic stroke treated at a stroke care unit.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
T ShimoyamaK Kimura

Abstract

Urinary liver-type fatty-acid binding protein (L-FABP), which is a biomarker of kidney tubule injury, has been studied extensively and established as a risk marker of acute kidney injury (AKI). The aim of this study was to investigate whether kidney tubule injury is associated with the development of AKI and mortality in patients with acute ischaemic stroke. Acute ischaemic stroke patients hospitalized in the stroke care unit (SCU) within 24 h after symptom onset were prospectively investigated. AKI was defined on the basis of Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Baseline urinary L-FABP was measured on admission. We evaluated the associations among urinary L-FABP, incidence of AKI, and 90-day mortality adjusted for renal function, albuminuria and other potentially predictive variables, using multivariable analysis. In total, 527 acute ischaemic stroke patients (342 men, median age 74 years) were enrolled in the study. Twenty-seven patients (5.1%) experienced AKI within 7 days of admission. In the univariate analysis, high urinary L-FABP level had positive associations with AKI [53.8 μg/g creatinine (Cr) vs. 3.9 μg/g Cr; P < 0.001] and 90-day mortality (15.5 μg/g Cr vs. 4.0 μg/g Cr; P < 0.001). In the mult...Continue Reading

References

Jan 4, 1991·Biochimica Et Biophysica Acta·J H VeerkampR G Maatman
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Apr 17, 2004·Kidney International·Edith M SimmonsUNKNOWN PICARD Study Group
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Jonathan Himmelfarb The PICARD Group
Oct 7, 2004·The American Journal of Pathology·Atsuko KamijoKenjiro Kimura
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Tokunori YamamotoTakeshi Sugaya
Jun 28, 2011·Critical Care Medicine·Kent DoiEisei Noiri
Nov 19, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Katsuomi MatsuiKenjiro Kimura
Jan 25, 2012·The Annals of Thoracic Surgery·Daisuke KatagiriEisei Noiri
Oct 10, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN Ad-hoc working group of ERBPWim Van Biesen
Jun 4, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Atsuko Kamijo-IkemoriKenjiro Kimura
Sep 18, 2014·Kidney International·Sharidan K ParrEdward D Siew
Mar 5, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Atsuko Kamijo-IkemoriYugo Shibagaki
Mar 5, 2017·Stroke; a Journal of Cerebral Circulation·Stacie L DemelDawn O Kleindorfer
Jun 1, 2017·Lancet·Jill VanmassenhoveWim Van Biesen
Jan 18, 2019·Nature Reviews. Nephrology·Chunyuan GuoZheng Dong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.