Urinary bladder cancer: preoperative nodal staging with ferumoxtran-10-enhanced MR imaging

Radiology
Willem M L L G DesernoJelle O Barentsz

Abstract

To prospectively evaluate ferumoxtran-10-enhanced magnetic resonance (MR) imaging for nodal staging in patients with urinary bladder cancer. Fifty-eight patients with proved bladder cancer were enrolled. Results of MR imaging performed before and after injection of ferumoxtran-10 were compared with histopathologic results in surgically removed lymph nodes. High-spatial-resolution three-dimensional T1-weighted magnetization-prepared rapid acquisition gradient-echo (voxel size, 1.4 x 1.4 x 1.4 mm) and T2*-weighted gradient-echo (voxel size, 0.8 x 0.8 x 3.0 mm) sequences were performed before and 24 hours after injection of ferumoxtran-10 (2.6 mg iron per kilogram of body weight). On precontrast images, lymph nodes were defined as malignant by using size and shape criteria (round node, >8 mm; oval, >10 mm axial diameter). On postcontrast images, nodes were considered benign if there was homogeneous decrease in signal intensity and malignant if decrease was absent or heterogeneous. Qualitative evaluation was performed on a node-to-node basis. Sensitivity, specificity, predictive values, and accuracy were evaluated with logistic regression analysis. In 58 patients, 172 nodes imaged with use of ferumoxtran-10 were matched and correla...Continue Reading

References

May 1, 1986·Microvascular Research·L E Gerlowski, R K Jain
Dec 1, 1984·Radiology·G C DoomsC B Higgins
Oct 7, 1997·JAMA : the Journal of the American Medical Association·J ScheidlerM R Segal
Mar 19, 1999·Der Urologe. Ausg. A·R BachorR Hautmann
Jul 27, 2000·The New England Journal of Medicine·R M PietermanH J Groen
Aug 6, 2000·European Journal of Radiology·M F BellinS Precetti-Morel
Dec 6, 2000·Journal of Magnetic Resonance Imaging : JMRI·H K PannuD A Bluemke
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P SteinD G Skinner
Jun 27, 2002·Zentralblatt für Chirurgie·J LeissnerH K Wolf
Jul 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·Constanze StetsSylvia H Heywang-Köbrunner
Aug 22, 2002·Academic Radiology·Mukesh G HarisinghaniRalph Weissleder
Jun 20, 2003·The New England Journal of Medicine·Mukesh G HarisinghaniRalph Weissleder

❮ Previous
Next ❯

Citations

Mar 29, 2006·Der Urologe. Ausg. A·J Gschwend
Dec 3, 2008·Der Urologe. Ausg. A·J Stattaus, M Forsting
Mar 10, 2010·Der Urologe. Ausg. A·M SeitzC Stief
Mar 14, 2013·Der Urologe. Ausg. A·T MaurerJ E Gschwend
Nov 30, 2006·Abdominal Imaging·N MorisawaK Togashi
May 9, 2006·Abdominal Imaging·A SaokarM Harisinghani
Aug 10, 2006·Abdominal Imaging·D M KohJ E Husband
Nov 15, 2006·World Journal of Urology·Mansi A SaksenaMukesh G Harisinghani
Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshiaki TatsumiIsamu Narabayashi
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J-M CorreasO Hélénon
Sep 5, 2008·Nature Clinical Practice. Urology·Mohamed A Ghoneim, Hassan Abol-Enein
May 5, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·G S PatelT Ng
May 31, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·P Tsakiris, J de la Rosette
May 6, 2009·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·B B PultrumG M van Dam
Mar 17, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Craig R ButlerIan Paterson
Apr 12, 2013·BMC Medicine·Shaista Hafeez, Robert Huddart
Mar 23, 2007·AJR. American Journal of Roentgenology·Leopoldo RubaltelliRoberto Stramare
Jul 25, 2007·AJR. American Journal of Roentgenology·Derk D PurcellBenjamin M Yeh
Aug 22, 2009·AJR. American Journal of Roentgenology·Pari V PandharipandeMukesh G Harisinghani
May 22, 2009·AJR. American Journal of Roentgenology·Raghunandan VikramChaan S Ng
Jul 24, 2012·Radiology·Moritz F Kircher, Jürgen K Willmann
Jan 17, 2014·Current Urology Reports·Ansje S FortuinJelle O Barentsz
Nov 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alexander SturzuStefan Heckl
May 23, 2014·AJR. American Journal of Roentgenology·Robbert J de HaasJurgen J Fütterer
Jan 25, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Blanca PañoCarlos Nicolau
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jade J Wong-You-CheongIsabell A Sesterhenn
Nov 15, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ajay K SinghMukesh G Harisinghani
Dec 5, 2006·Current Opinion in Urology·Marie-France Bellin, Catherine Roy
Dec 20, 2007·Current Opinion in Urology·Dirk BeyersdorffHedvig Hricak
Jul 14, 2010·Current Opinion in Urology·Nigel C Cowan, Jeremy P Crew
Feb 12, 2011·Current Opinion in Urology·Agostino Mattei, Hansjörg Danuser
Nov 30, 2010·Expert Review of Anticancer Therapy·Mohummad Minhaj Siddiqui, Adam S Feldman
Jun 29, 2011·Expert Review of Anticancer Therapy·Anirban P Mitra, Richard J Cote
May 6, 2014·Magnetic Resonance Imaging Clinics of North America·Seyed Mahdi AbtahiSandeep S Hedgire

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.