Urinary bladder dose-response relationships for patient-reported genitourinary morbidity domains following prostate cancer radiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Maria ThorJoseph O Deasy

Abstract

Radiotherapy (RT) induced genitourinary (GU) morbidity is typically assessed by physicians as single symptoms or aggregated scores including symptoms from various domains. Here we apply a method to group patient-reported GU symptoms after RT for localized prostate cancer based on their interplay, and study how these relate to urinary bladder dose. Data were taken from two Scandinavian studies (N=207/276) including men treated with external-beam RT (EBRT) to 78/70Gy (2Gy/fraction; median time-to-follow-up: 3.6-6.4y). Within and across cohorts, bladder dose-volume parameters were tested as predictors for GU symptom domains identified from two study-specific questionnaires (35 questions on frequency, incontinence, obstruction, pain, urgency, and sensory symptoms) using univariate and multivariate logistic regression analysis (MVA) with 10-fold cross-validation. Performance was evaluated using Area Under the Receiver Operating Characteristic Curve (Az). For the identified Incontinence (2-5 symptoms), Obstruction (3-5 symptoms), and Urgency (2-7 symptoms) domains, MVA demonstrated that bladder doses close to the prescription doses were the strongest predictors for Obstruction (Az: 0.53-0.57) and Urgency (Az: 0.60). For Obstruction, ...Continue Reading

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Citations

Jul 3, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Noorazrul YahyaJames W Denham
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Antoine SimonRenaud de Crevoisier
Feb 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Eugenia MylonaRenaud de Crevoisier
May 1, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yvette SeppenwooldeDietmar Georg

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