Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report

BMC Cancer
Vincenzo FiorentinoMaurizio Martini

Abstract

Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis. A 86-year-old male patient was referred to our institution to undergo endoscopic low-urinary-tract re-evaluation 2 months after the detection of a "low-grade urothelial neoplasia" in urinary cytology. A TURBT (transurethral resection of bladder tumor) was performed and revealed a tumor extending for 3.5 cm with thin stalk peduncle on the left lateral wall of the bladder, cephalad and lateral to the left ureteral orifice. The exophytic part of the tumor was resected with the underlying bladder wall. Histologically, the tumor showed a quite complex pattern, composed of spindle cells, with often invasion to the surrounding bladder muscular wall, and the presence of numerous multinucleated, osteoclast-like giant cells, scattered throughout the neoplasia. Here we report a unique case of urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells (OGCs). These cells, confounding the morphological aspect, indeed showed an immunohistochemical phenotype of non-neoplastic origin (most likely a histiocyte/macrophage diffe...Continue Reading

References

Feb 1, 1992·Histopathology·K J DentonN Athanasou
Nov 1, 1990·Histopathology·G Amir, E Rosenmann
Jun 1, 1991·The American Journal of Surgical Pathology·L R ZukerbergR H Young
May 1, 1972·The Journal of Pathology·R Salm, H A Sissons
Jun 1, 1972·Cancer·J G Guccion, F M Enzinger
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·M Lorentzen
Apr 1, 1995·The American Journal of Surgical Pathology·K T Chen
Apr 1, 1995·American Journal of Clinical Pathology·V Stracca-PansaG Pettinato
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Pedersen-BjergaardK Hou-Jensen
Mar 29, 2000·CA: a Cancer Journal for Clinicians·R T GreenleeP A Wingo
Aug 15, 2001·Journal of Cancer Research and Clinical Oncology·M WüllingE Kaiser
Dec 3, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dilek BaydarJonathan I Epstein
Jan 9, 2007·Urologic Oncology·Philippe E SpiessH Barton Grossman
Mar 23, 2010·World Journal of Surgical Oncology·Enzo RicciardiMassimo Moscarini
Jul 17, 2014·Urologic Oncology·Dayron RodríguezAdam S Feldman
Aug 19, 2015·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Dewen ZhongHuaijing Luo
Jul 21, 2016·Journal of Clinical and Diagnostic Research : JCDR·José G A RibeiroMarcio A Babinski
Nov 22, 2016·Current Urology·Mathew FakhouryMarc A Bjurlin
Jun 7, 2018·Journal of Cell Science·Marie PereiraJacques Behmoaras

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
surgical resection
SMA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cytology
Shanthakumari SivanandhamK Rajeshwari Muthusamy
The American Journal of Surgical Pathology
K T Chen
© 2021 Meta ULC. All rights reserved