Urinary Bladder Matrix Protects Host in a Murine Model of Bacterial-Induced Lung Infection

Tissue Engineering. Part a
Chen ChenYuanpu Peter Di

Abstract

Lung infection is a leading cause of human life lost to morbidity and/or mortality. This problem is exacerbated by the alarming emergence of increasingly antibiotic-resistant (AR) microorganisms worldwide and the lack of effective antimicrobials to overcome the AR bacterial infection. Urinary bladder matrix (UBM) is a biologically derived scaffold material that has been used to promote site-appropriate tissue regeneration and remodeling in a variety of body systems. Our novel findings demonstrate that the preformulated UBM effectively protects the host from methicillin-resistant Staphylococcus aureus (MRSA)- and Pseudomonas aeruginosa-induced murine pneumonia and may provide a viable alternative/supplement for protection against respiratory AR bacterial infection.

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Citations

Feb 3, 2021·ACS Biomaterials Science & Engineering·Qiao LinYuan-Pu Peter Di

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Methods Mentioned

BETA
bronchoalveolar
lavage
PCR
bronchoalveolar lavage

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