Urinary C-Peptide/Creatinine Ratio Can Distinguish Maturity-Onset Diabetes of the Young from Type 1 Diabetes in Children and Adolescents: A Single-Center Experience

Hormone Research in Pædiatrics
Sebahat Yılmaz AgladiogluZehra Aycan

Abstract

The urinary C-peptide/creatinine ratio (UCPCR) and fasting C-peptide level can assess beta-cell function in clinical practice. In the present study, the use of the UCPCR and fasting C-peptide levels was investigated in the differential diagnosis between maturity-onset diabetes of the young (MODY) and type 1 diabetes mellitus (T1DM). Twenty-seven patients with genetically confirmed MODY by next-generation sequence analysis and 42 children with T1DM were included. C-peptide levels were measured after an overnight fast before breakfast, and urine samples were collected 2 h after a standard lunch in the hospital. The UCPCR in the T1DM group was 0.17 ± 0.5 nmol/mmol, and in the MODY group it was 1.27 ± 1.03 nmol/mmol (p = 0.001). The receiver operating characteristic (ROC) curves showed excellent discrimination (area under the curve 0.93). A UCPCR ≥0.22 nmol/mmol yielded a 96.3% sensitivity and an 85.7% specificity. The fasting C-peptide level in the T1DM group was lower than that in the MODY group (p = 0.001). The fasting C-peptide cutoff determined by ROC curve analysis was 0.62 ng/ml, with a sensitivity of 93% and a specificity of 90% for discriminating between MODY and T1DM. We showed that the UCPCR and fasting C-peptide levels ...Continue Reading

Citations

Feb 14, 2020·European Journal of Pediatrics·Wafaa ElzaharDoaa El Amrousy
Jun 13, 2020·Diabetology & Metabolic Syndrome·Renata Peixoto-BarbosaFernando M A Giuffrida
Jan 23, 2018·Diabetes Technology & Therapeutics·Shideh MajidiAndrea K Steck
Feb 3, 2021·The Journal of Clinical Investigation·Haichen ZhangToni I Pollin

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