Urinary catecholamines and the relationship with blood pressure and pharmacological therapy

Journal of Hypertension
Constantinos G MissourisGraham A MacGregor

Abstract

Our aim was to assess the importance of the sympathetic nervous system as assessed by urinary catecholamine measurement in the aetiology of essential hypertension and the importance of antihypertensive therapy in the excretion of urinary catecholamines. Twenty-four-hour urinary catecholamine measurement was performed in 1925 patients who were referred for treatment of hypertension and grouped according to the Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure classification: of the 655 untreated patients, 59 were normotensive individuals (SBP < 140 and DBP < 90 mmHg), n = 219 stage 1 (SBP 140-159 or DBP 90-99 mmHg), n = 236 stage 2 (SBP 160-179 or DBP 100-109 mmHg) and n = 141 stage 3 (SBP ≥ 180 or DBP ≥ 110 mmHg). There was a statistically significant positive relationship between 24-h urinary norepinephrine excretion and the severity of hypertension, such that the higher the blood pressure the higher the urinary norepinephrine excretion (mean ± standard error of mean): normotensive group, 221 ± 13 nmol/24 h; stage 1, 254 ± 8 nmol/24 h; stage 2, 263 ± 7 nmol/24 h and stage 3, 296 ± 12 nmol/24 h (P < 0.001). The above relationship remained highly significant w...Continue Reading

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Citations

Mar 5, 2016·Journal of Hypertension·Jens Jordan, Guido Grassi
Sep 9, 2020·European Journal of Hospital Pharmacy. Science and Practice·Qingrong JiYing Chang
Oct 20, 2020·Frontiers in Endocrinology·Claudia BoettcherStefan A Wudy
Aug 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Simone R PotjeAndreia Z Chignalia

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