Urinary Concentration Correction Methods for Arsenic, Cadmium, and Mercury: a Systematic Review of Practice-Based Evidence

Current Environmental Health Reports
Chun-Yu HsiehChin-Chi Kuo

Abstract

Urinary biomonitoring is widely used to assess environmental chemical exposure; however, a critical gap exists in whether and how to correct for the physiological variation in water content of spot urine samples. The aim of this systematic review is to summarize the available evidence comparing the performance of urinary concentration correction methods used to determine urinary levels of arsenic, cadmium, and mercury. We searched PubMed/MEDLINE, Embase, LILIAC, Web of Science, and TOXNET up to Sept. 5, 2017 for articles evaluating urinary concentration correction methods (e.g., urine creatinine [U-Cre], specific gravity [U-SG], osmolality [U-Osm]) compared to 24-h or timed urine specimens for levels of arsenic, cadmium, and mercury. Data on study design, methods of urine collection, and the performance of selected correction methods were extracted. A total of 10 papers met the inclusion criteria. Two papers evaluated the performance of urinary concentration correction methods for arsenic, four for cadmium, three for mercury, and one for multiple metals. The median sample size for arsenic was 105, for cadmium 107, and for mercury 35. The studies were highly heterogeneous in population selection, urine collection, urine quality ...Continue Reading

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Aug 24, 2020·The Science of the Total Environment·Yuko TakayamaKatsuyuki Murata
Feb 14, 2021·International Journal of Hygiene and Environmental Health·Lars BarregardGerd Sallsten
Jun 7, 2021·Environmental Research·Anne E NigraAna Navas-Acien

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Methods Mentioned

BETA
urine collection
urine specimen collection
urine sampling

Software Mentioned

Cre

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