PMID: 7054236Jan 1, 1982Paper

Urinary concentration in the papillary collecting duct of the rat. Role of the ureter

The Journal of Clinical Investigation
R E OliverR L Jamison

Abstract

Urine was observed to flow intermittently in the collecting ducts of the extrarenal papilla of antidiuretic rats. The purpose of this investigation was to test Reinking and Schmidt-Nielsen's hypothesis that intermittent flow plays an important role in the production of maximally concentrated urine. Samples of collecting duct fluid were obtained from the base and tip of the papilla by micropuncture through the intact ureter. Fluid osmolality rose sharply from base, 894+/-120 mosmol/kg H(2)O(-1) (mean+/-SE), to tip, 1,667+/-114 (P<0.001), a distance of only 2 mm, and was due exclusively to reabsorption of water. After excision of the ureter, which abolished intermittent flow, osmolality fell modestly at the base to 723+/-82 mosmol/kg H(2)O(-1) (P < 0.02), but strikingly at the tip to 1,012+/-103 (P < 0.001). The pelvic ureter was paralyzed by topical verapamil and dimethylsulfoxide, which abolished intermittent flow. Osmolality of urine at the tip was not changed (1,959+/-184 mosmol/kg H(2)O(-1) before, vs. 1,957+/-126 after paralysis). The ureter was severed just beyond the papillary tip, a maneuver which preserved intermittent flow but abolished urinary reflux over the papilla. Urinary osmolality fell from 1,876+/-134 mosmol/kg...Continue Reading

References

Mar 1, 1978·The Journal of Clinical Investigation·E L ChuangJ H Stein
May 15, 1978·Experientia·C E ConstantinouM Mensah-Dwumah
Feb 1, 1975·The Journal of Clinical Investigation·J P PennellR L Jamison
Jan 1, 1972·Pflügers Archiv : European journal of physiology·W Schütz, J Schnermann
Nov 1, 1971·The Journal of Clinical Investigation·R L JamisonF Lacy
Jul 1, 1981·Kidney International·L N Reinking, B Schmidt-Nielsen

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Citations

Jun 15, 1984·Experientia·L N Reinking, M C Veale
Oct 20, 2005·American Journal of Physiology. Renal Physiology·Mary Ella C PruittBodil Schmidt-Nielsen
Nov 1, 1984·The Journal of Clinical Investigation·J BargmanR L Jamison
Oct 16, 2001·The Journal of Physiology·O TenstadK Aukland
Feb 1, 1987·Kidney International·B Schmidt-Nielsen
Feb 1, 1987·Kidney International·B L ZimmerhacklR L Jamison
Jan 1, 1990·Kidney International·S Y ChouP F Faubert
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·S Randall Thomas
Jan 1, 1988·Journal of Mathematical Biology·J B Garner, R B Kellogg
Sep 1, 1983·Circulation Research·C HolligerR L Jamison
Dec 1, 1993·Journal of Morphology·N S R Maluf
Jan 1, 1983·The Anatomical Record·R E Bulger, D C Dobyan
Sep 1, 1991·The Anatomical Record·N S Maluf
Dec 1, 1987·The American Journal of Anatomy·N S Maluf
Feb 9, 2000·American Journal of Physiology. Renal Physiology·A EdwardsT L Pallone
Jan 31, 2003·American Journal of Physiology. Renal Physiology·Mark A KnepperTerry Dwyer
Apr 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas L PalloneRex L Jamison
Jul 18, 2019·American Journal of Physiology. Renal Physiology·Anita T Layton
Feb 1, 1989·The Journal of Urology·M KekomäkiC Bertényi
Dec 28, 2018·Toxicologic Pathology·Björn JacobsenBarbara Lenz

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