Urinary concentrations and profiles of organophosphate and pyrethroid pesticide metabolites and phenoxyacid herbicides in populations in eight countries

Environment International
Adela Jing Li, Kurunthachalam Kannan

Abstract

Concentrations of nine metabolites of organophosphate and pyrethroid insecticides, as well as two phenoxy herbicides, were determined in 322 urine samples collected from eight countries during 2006-2014 by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The target pesticides were found ubiquitously, indicating widespread exposure of humans to pesticides in these countries. The highest sum concentrations of 11 pesticides were found in urine collected from Vietnam (median, 28.9 ng/mL), followed in decreasing order by samples from India (14.2 ng/mL), China (13.6 ng/mL), Korea (12.5 ng/mL), Greece (12.3 ng/mL), Saudi Arabia (11.3 ng/mL), the USA (7.9 ng/mL), and Japan (7.1 ng/mL). Organophosphorus compounds accounted for 62-77% of the total urinary pesticide concentrations. Para-nitrophenol (metabolite of parathion and methyl parathion) and 3,5,6-trichloro-2-pyridinol (metabolite of chlorpyrifos and chlorpyrifos-methyl) were the major metabolites, especially in India (72%), China (69%), and Greece (66%). Differences in urinary pesticide concentrations between genders (male vs. female), age groups (categorized as ≤20, 21-49, and ≥50 years), and cities (Guangzhou, Shanghai, and Qiqihar) were examined. On...Continue Reading

Citations

Aug 29, 2020·International Journal of Environmental Research and Public Health·Arin A BalalianRobin Whyatt
Jan 5, 2021·Environmental Science and Pollution Research International·Toshiaki YoshidaNaomi Sakon
Jan 2, 2021·International Journal of Environmental Research and Public Health·Cynthia L CurlRebecca L Som Castellano
Jan 22, 2021·Journal of Exposure Science & Environmental Epidemiology·Cynthia L CurlKurunthachalam Kannan
Nov 5, 2019·The Science of the Total Environment·Sandra F FernándezUNKNOWN BETTERMILK
Mar 8, 2021·Journal of Exposure Science & Environmental Epidemiology·Derek W WerthmannGinger L Chew
Apr 7, 2021·Critical Reviews in Toxicology·Anandha Rao Ravula, Suresh Yenugu
Apr 12, 2021·Environment International·Feng-Jiao PengUNKNOWN NESCAV project group for the Grand Duchy of Luxembourg
Apr 12, 2021·Environmental Pollution·Hongxiu LiuAkhgar Ghassabian
Apr 7, 2021·Environmental Toxicology and Chemistry·Collins NimakoMayumi Ishizuka
Aug 4, 2021·Environmental Health : a Global Access Science Source·Charles BenbrookRobin Mesnage

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