Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel

Environment International
Ronit MachtingerRavit Nahum

Abstract

Mounting evidence suggests possible adverse effects of intrauterine exposure to certain phenols and phthalates, two classes of endocrine disruptor chemicals, on the developing fetus, with consequences into later life. These findings have contributed to the replacement of some chemicals, such as di‑2‑ethylhexyl phthalate (DEHP) and bisphenol A (BPA), in consumer products. For the current study we quantified urinary concentrations of biomarkers of exposure among 50 pregnant women in Israel to several phthalates, bisphenols and personal care product chemicals, as well as DEHP and BPA alternatives. We detected 14 of the 31 biomarkers in more than 90% of the women. We detected biomarkers of 1,2‑cyclohexane dicarboxylic acid, diisononyl ester (DINCH), bisphenol S, and bisphenol F not as frequently (27-56%). This study is the first to evaluate exposure to triclosan, bisphenols, parabens, and phthalates and BPA alternatives among Israeli pregnant women.

Citations

Jul 28, 2020·Environmental Health Perspectives·Michiel A van den DriesAnjoeka Pronk
Sep 22, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Prabin ShresthaTit-Yee Wong
Aug 19, 2020·Clinical Endocrinology·Valentina GalianoRonit Machtinger
Feb 5, 2021·Environmental Science and Pollution Research International·Jin QinBo Chen
Apr 27, 2021·The Science of the Total Environment·Fei-Peng CuiQiang Zeng
May 21, 2021·Reproductive Toxicology·Genoa R WarnerJones B Graceli
Jun 22, 2021·Journal of Environmental Health Science & Engineering·Xueyan ChenWenbo Li
Jun 11, 2019·Environmental Science & Technology·Jiufeng LiZongwei Cai

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