Urinary copper/zinc ratio: a promising parameter for replacement of 24-hour urinary copper excretion for diagnosis of Wilson's disease in children.

World Journal of Pediatrics : WJP
Jian-She WangQi-Rong Zhu

Abstract

Although 24-hour urinary copper excretion is valuable for diagnosis of Wilson's disease, accurate, timed collection entails practical difficulties. This study aimed to investigate the feasibility of morning urinary copper/creatinine or copper/zinc ratio as replacement parameter for diagnosing Wilson's disease. Five random urinary samples collected during 24 hours from two inpatients were used to estimate the consistency of urinary copper/creatinine and copper/zinc ratios. The correlation of the ratios with 24-hour urinary copper excretion was studied in 15 patients with liver diseases. The diagnostic value of morning urinary copper/zinc ratio was further studied in 9 children with Wilson's disease and 22 children with other liver diseases. The coefficients of variation of urinary copper/creatinine and copper/zinc ratios during 24 hours were 12.5% and 9.3% respectively. The morning urinary copper/creatinine ratio, copper/zinc ratio, and 24-hour urinary copper excretion were correlated well. The area under receiver-operating characteristic curve was comparable between the morning urinary copper/zinc ratio and 24-hour urinary copper excretion (0.983 vs. 0.977). Morning urinary copper/zinc ratio seems to be a promising parameter in...Continue Reading

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Citations

Jul 29, 2017·Archives of Disease in Childhood. Education and Practice Edition·Jane Armer, Christian De Goede
May 16, 2018·Frontiers in Pediatrics·Sarah GuttmannHartmut H Schmidt
Dec 29, 2020·Journal of Pediatric Gastroenterology and Nutrition·Atchariya Chanpong, Anil Dhawan

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