PMID: 7520976Sep 1, 1994Paper

Urinary cyclophosphamide excretion and chromosomal aberrations in peripheral blood lymphocytes after occupational exposure to antineoplastic agents

Mutation Research
P J SessinkR P Bos

Abstract

In this study we have compared the results of a method for the detection of cyclophosphamide in urine and the results of analysis of chromosomal aberrations in peripheral blood lymphocytes of four groups of subjects with various exposure statuses. These groups are 17 Dutch and 11 Czech exposed workers (mainly hospital nurses and pharmacy technicians) handling antineoplastic agents and 35 Dutch and 23 Czech controls (nurses, medical doctors, pharmacy and lab technicians) not handling these drugs. The groups were subdivided into smokers and non-smokers because of a confounding effect of smoking. Within the Dutch groups, the percentage of aberrant cells and the number of breaks per cell were increased for smokers compared to non-smokers. The percentage of aberrant cells was increased in Dutch exposed workers in comparison with Dutch control workers. Within the Czech groups the percentage of aberrant cells and the number of breaks per cell were increased in exposed workers in comparison with control workers. However, both Dutch and Czech smokers mainly contributed to the increase. The results suggest an additive effect of exposure and smoking in the Dutch subjects and a more than additive effect in the Czech subjects. In urine samp...Continue Reading

References

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Citations

Jan 1, 1995·International Archives of Occupational and Environmental Health·P J SessinkR P Bos
May 12, 2005·International Archives of Occupational and Environmental Health·Wouter FransmanHans Kromhout
Apr 25, 2012·International Archives of Occupational and Environmental Health·Laetitia Minh Mai LêEric Caudron
May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roberta TurciClaudio Minoia
Mar 23, 2001·Journal of Toxicology and Environmental Health. Part a·M G JakabA Tompa
Jan 28, 2010·Journal of Veterinary Internal Medicine·A KnoblochD Simon
Jan 28, 2010·Journal of Veterinary Internal Medicine·A KnoblochD Simon
Jan 1, 1997·Reviews on Environmental Health·R P Bos, P J Sessink
Feb 21, 2008·Journal of Occupational Health·Loredana CastigliaMaria Virginia Scafarto
Nov 5, 2014·International Archives of Occupational and Environmental Health·Massimo MorettiSilvano Monarca
Jul 22, 2016·Clinical Journal of Oncology Nursing·Seth Eisenberg
Sep 28, 2016·Journal of Occupational and Environmental Hygiene·Thomas Kibby
Sep 1, 1995·Archives of Environmental Health·P Joseph
May 18, 2010·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Shinichi SugiuraToshitaka Nabeshima
Feb 17, 2010·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Paul J M SessinkTimothy G Tyler
Jul 13, 2005·Journal of Occupational and Environmental Medicine·Melissa A McDiarmid, Marian Condon
Oct 6, 2006·International Archives of Occupational and Environmental Health·Wouter FransmanHans Kromhout
Feb 1, 2014·Journal of Occupational and Environmental Medicine·Raveena RamphalNicholas Barrowman
Feb 26, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Paul Jm SessinkNassima Kassoul
Oct 13, 2012·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Michiko YukiPaul J M Sessink
Mar 30, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Bruce W ChaffeeKimberly A Redic
Oct 5, 2018·Arhiv za higijenu rada i toksikologiju·Susana ViegasMário Pádua
Oct 29, 2002·Journal of Environmental Monitoring : JEM·Olle NygrenArne Friberg
Mar 5, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Thomas H ConnorRobert Dechristoforo

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