Urinary cysteinyl leukotriene E(4) is associated with increased risk for pain and acute chest syndrome in adults with sickle cell disease

American Journal of Hematology
Joshua J FieldMichael DeBaun

Abstract

Leukotriene E(4) (LTE(4)) levels are associated with rate of pain episodes in children with sickle cell disease (SCD). Because complications of SCD manifest differently in adults than children, we examined a cohort of adults with SCD to determine the relationship between baseline LTE(4) and SCD-related morbidity. Baseline LTE(4) levels were associated with increased rates of pain and acute chest syndrome (ACS) episodes, when those with LTE(4) values in the highest tertile were compared with those in the lowest tertile (pain: risk ratio 7.1, 95% CI 1.8-27.5, P = 0.005; ACS: risk ratio 12.2, 95% CI 2.1-69.8, P = 0.005).

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Citations

Apr 15, 2011·Anemia·Kathryn Blake, John Lima
Dec 17, 2009·Hematology·Joshua J Field, Michael R DeBaun
Aug 1, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Amma Owusu-AnsahSolomon F Ofori-Acquah
Aug 3, 2011·American Journal of Hematology·Robyn T CohenJoshua J Field
May 28, 2011·European Journal of Haematology·Rabindra N PaulPatricia A Oneal
Dec 11, 2013·BioMed Research International·Esteban Gomez, Claudia R Morris
May 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Paula T MonteiroClaudio Canetti
Oct 1, 2011·Expert Review of Respiratory Medicine·Samuel O AnimMichael R DeBaun
Mar 26, 2020·Blood Advances·Joshua J FieldMichael R DeBaun
Jan 1, 2018·Expert Opinion on Orphan Drugs·Kenneth I Ataga, Payal C Desai
May 16, 2019·Current Opinion in Pediatrics·Shaina M WillenMichael R DeBaun

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