Urinary Cytomegalovirus Shedding in the United States: The National Health and Nutrition Examination Surveys, 1999-2004

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Minal M AminChengbin Wang

Abstract

There are no data on the prevalence of cytomegalovirus (CMV) shedding from a representative sample of the US population. This information is critical for understanding and preventing CMV. We tested urine specimens from CMV immunoglobulin (Ig) G-positive participants aged 6-49 years in 3 racial/ethnic groups from the National Health and Nutrition Examination Surveys 1999-2004 for the presence of CMV DNA using real-time polymerase chain reaction assay. We examined the association of sociodemographic characteristics with shedding prevalence and viral loads. Among 6828 CMV IgG-positive participants tested, 537 had CMV DNA detected in urine-a shedding prevalence of 9.70%. Among persons aged 6-49 years, shedding prevalence was 3.83%. The prevalence of urinary shedding was inversely associated with increasing age (26.60%, 6.50%, and 3.45% in CMV IgG-positive participants aged 6-11, 12-19, and 20-49 years, respectively; P < .001 for trend test and pairwise comparisons). Urinary viral load also decreased significantly with age (mean, 2.97, 2.69, and 2.43 log10 copies/mL in those age groups, respectively; P < .001 for trend test and pairwise comparisons). Urinary CMV shedding and viral loads decreased dramatically with age, likely reflec...Continue Reading

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Citations

Mar 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis-Marie YindomSarah L Rowland-Jones
Mar 7, 2020·The Journal of Infectious Diseases·Cody S NelsonSallie R Permar
Oct 28, 2019·International Journal of Molecular Sciences·Shelley WatersPatricia Price
Aug 8, 2021·Journal of the Pediatric Infectious Diseases Society·Minal M AminSheila C Dollard

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