Urinary engrailed-2 (EN2) levels predict tumour volume in men undergoing radical prostatectomy for prostate cancer

BJU International
Hardev S PandhaRichard Gl Morgan

Abstract

What's known on the subject? and What does the study add? There are a lot of potential prostate cancer biomarkers being evaluated. All aim to improve on the sensitivity and specificity of PSA. EN2 was recently shown by our group to have better sensitivity and specificity than PSA. EN2 is a simple ELISA test and is not dependent on other parameters, even PSA, unlike all the other current biomarkers under evaluation. To date, no marker correlates with the amount of cancer present - the present study shows this positive correlation with EN2 in men undergoing prostatectomy. The potential utility of this work is that by knowing that the level of EN2 corresponds to the amount of cancer present, irrelevant of tumour grade and number of cancer foci, we can define an EN2 level corresponding to small cancers, which can then undergo surveillance. We are conducting a further study that is aimed at determining whether the levels of EN2 in urine can indicate 'significant' vs 'non-significant cancer' using the threshold of 0.5 mL cancer (after Epstein's work). To evaluate the relationship between levels of a recently described prostate cancer biomarker engrailed-2 (EN2) in urine and cancer volume in men who had undergone radical prostatectomy...Continue Reading

References

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Citations

Nov 26, 2013·Biomarkers in Medicine·Sophie E McGrathHardev Pandha
Feb 12, 2013·FEBS Letters·Sophie E McGrathRichard Morgan
Oct 23, 2015·Expert Review of Molecular Diagnostics·Maria FrantziHarald Mischak
Nov 29, 2015·The Urologic Clinics of North America·Jeffrey J TosoianChristian P Pavlovich
Mar 25, 2014·Clinical and Experimental Immunology·N E AnnelsH Pandha
Jan 11, 2013·Prostate Cancer·Siebren DijkstraJack A Schalken
Feb 26, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Richard MorganHardev Pandha
May 28, 2013·International Journal of Molecular Sciences·Vicki M VelonasStephen J Assinder
Oct 5, 2017·Revista da Associação Médica Brasileira·Maria Inês da RosaAntonio José Grande
Feb 28, 2013·Nature Reviews. Urology·Steven L WoodRosamonde E Banks
Aug 22, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazutoshi Fujita, Norio Nonomura
Jan 19, 2019·Prostate Cancer and Prostatic Diseases·Jillian N EskraJun Luo
Nov 7, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Joana Do Carmo SilvaMarko Babjuk
Jun 5, 2016·Current Opinion in Urology·Stacy LoebAndrew Vickers
Mar 28, 2017·Journal of Clinical Urology·Niels Asger JakobsenRichard John Bryant
Mar 8, 2016·Journal of Molecular Histology·Cai-Yong LaiZe-Xuan Su
Sep 11, 2019·Journal of Clinical Medicine·Enrique Gómez-GómezRaúl M. Luque
Oct 5, 2018·BMC Cancer·Sophie Elena McGrathAgnieszka Michael
Apr 2, 2021·Frontiers in Oncology·Marina Y ZemskovaKonstantin S Sorokin
Jun 27, 2021·Pharmacology & Therapeutics·Maria Adamaki, Vassilios Zoumpourlis

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