PMID: 1201612Dec 1, 1975Paper

Urinary enzyme excretion during renal papillary necrosis induced in rats with ethyleneimine

Chemico-biological Interactions
B G Ellis, R G Price

Abstract

N-Acetyl-beta-glucosaminidase, beta-galactosidase, beta-glucosidase, acid and alkaline phosphatase were monitored in urine kidney homogenates and serum of rats with papillary damage induced with ethyleneimine. Serum urea levels, total protein in the urine and urine volume were monitored throughout the study. Histological studies showed that the injection of ethyleneimine caused immediate papillary necrosis, followed later by secondary cortical involvement. Minor papillary necrosis induced by a low dose (0.5 mul/kg) of ethyleneimine was characterised by a rise in urinary N-acetyl-beta-glucosaminidase activity which was followed later by an increase in the activity of the other enzymes monitored. More severe papillary necrosis induced with a higher dose of ethyleneimine (5.0 mul/kg) resulted in an immediate rise in the activities of all the urinary enzymes which then decreased only to rise again when cortical involvement occurred. Serum urea was unaltered but urine volume and protein were increased coincidentally with the urinary enzyme activities. The value of the assay of urinary enzymes in distinguishing papillary from glomerular and tubular damage is assessed. The possible relevance of the ethyleneimine model to the etiology ...Continue Reading

References

Jan 1, 1973·Clinical Toxicology·W F Clark, A L Linton
Nov 27, 1971·British Medical Journal·I C CalderJ D Tange
Jan 1, 1968·Nephron·A F Burry
Aug 16, 1965·JAMA : the Journal of the American Medical Association·M R SCHOENFELD

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Citations

Mar 1, 1985·Bulletin of Environmental Contamination and Toxicology·S D HarrisonR C Giles
Feb 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·E HolmesJ K Nicholson
Jun 1, 1984·The American Journal of Medicine·B R MeyerM M Reidenberg
Jan 1, 1985·Critical Reviews in Toxicology·P H Bach, J W Bridges
Dec 1, 1982·Cancer Chemotherapy and Pharmacology·S D HarrisonR C Giles
Jan 1, 1985·CRC Critical Reviews in Toxicology·P H Bach, J W Bridges

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