Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs

Renal Failure
E A BurdmannG Porter

Abstract

Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and of alanine-aminopeptidase (AAP) was studied after administration of cyclosporine A (CSA A), FK 506, or the corresponding vehicles to salt-depleted rats. On days 7, 14, and 28 after treatment for CSA and day 14 after treatment for FK 506, measurements of the urinary enzymes, serum creatinine (SCr), creatinine clearance (ClCr), and blinded renal histology were done. After 1 week on CSA there was a dramatic increase of 489% in the urinary excretion of AAP (162.6 IU/g Cr, CSA vs. 27.6 IU/g Cr control, p < .03), a significant decrease of 32% in ClCr, a significant increase of 41% in SCr, and mild proximal tubular atrophy and vacuolization. After 2 or 4 weeks of CSA treatment there were no more differences in the urinary AAP between CSA and control rats, but the urinary excretion of NAG was increased: 29.6 IU/g Cr, CSA vs. 20.9 IU/g Cr, control, p < .03 on day 14 and 26.9 IU/g Cr, CSA vs. 21.5 IU/g Cr, control, p < .008 on day 28. At the same time there was a progressive decline of the ClCr, a progressive increase in the SCr, and an increase in the severity of the histological lesion. After 14 days of treatment with FK 506 we observed a striking elevation in urinary AAP (...Continue Reading

References

Aug 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I E StillmanS Rosen
Nov 1, 1991·Gut·W G Thompson
Jul 1, 1986·Archives of Environmental Contamination and Toxicology·P W MuellerK K Steinberg
Jan 1, 1987·American Journal of Industrial Medicine·R R Lauwerys, A Bernard
Aug 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M D StonardI K Smith
Jan 1, 1985·Uremia Investigation·D T PlummerJ D Haslam
Aug 1, 1984·Kidney International·W G Guder, B D Ross
Jan 1, 1982·Toxicology·R G Price
Jan 1, 1984·Contributions to Nephrology·U C Dubach, M Le Hir

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Citations

Jan 15, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna WasilewskaJoanna Michaluk-Skutnik
Mar 19, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Shumpei Yokota
Oct 13, 2000·Fundamental & Clinical Pharmacology·T A MarsenC A Baldamus
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R K Rude
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K BonciminoE Shane
Feb 28, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Birgit HoldtMichael Steiner
Dec 8, 2010·Biomarkers in Medicine·Enver KhanJuan J L Lertora
Oct 4, 2006·Expert Opinion on Drug Metabolism & Toxicology·Vishal S Vaidya, Joseph V Bonventre
Mar 28, 2007·Journal of Pharmaceutical Sciences·M VogtD M Barends
Apr 17, 2001·Biopharmaceutics & Drug Disposition·M S Al-SaidQ Zaman Qumaruzaman
Feb 16, 2010·Life Sciences·Armin Farajzadeh DeroeeAhmad Reza Dehpour
Jan 16, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stuart M LichtmanMatti Aapro
Jul 23, 1999·Renal Failure·W F Finn
Jun 16, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B J PereiraL Yu
Nov 21, 2007·Journal of Clinical Laboratory Analysis·Ali Mohammadi-KarakaniRohollah Hosseini
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mònica GuevaraVicente Arroyo

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