PMID: 9175943May 1, 1997Paper

Urinary excretion of 5-L-oxoproline (pyroglutamic acid) during early life in term and preterm infants

Archives of Disease in Childhood. Fetal and Neonatal Edition
A A JacksonN Rutter

Abstract

Urinary 5-L-oxoproline was measured in term and preterm infants from shortly after birth until 6 weeks of postnatal age to determine their ability to synthesise glycine. In term infants the excretion was five to 10 times that seen in normal adults, increasing from 105 mumol/mmol creatinine in the first 72 hours after birth to 170 mumol/mmol creatinine at 6 weeks of age. There was a significant inverse linear correlation between the excretion of 5-L-oxoproline and length of gestation or birthweight. By 6 weeks of age there was no longer a significant difference in 5-L-oxoproline between term and preterm infants. There was no difference in the excretion of 5-L-oxoproline between boys and girls, or between infants fed on human milk or an artificial formula. If, in part, variability in the excretion of 5-L-oxoproline is determined by the extent to which the endogenous formation of glycine is adequate, then glycine formation may be marginal during early life, more so in preterm than in term infants, providing additional evidence that glycine is a conditionally essential amino acid in the neonate.

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Citations

Apr 15, 2004·Placenta·B J BrabinJ Ordi
Dec 19, 2002·Trends in Parasitology·Bernard J BrabinNicholas Brown
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Orson W Moe, Daniel Fuster
Apr 3, 2007·Orphanet Journal of Rare Diseases·Ellinor Ristoff, Agne Larsson
Apr 24, 2014·Drug Metabolism Reviews·Christoffel Petrus Stephanus BadenhorstAlberdina Aike van Dijk
Nov 26, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·J C Hall
Feb 26, 2016·International Journal of Molecular Sciences·Angelica DessìPierluigi Caboni
Oct 28, 1999·The Journal of Nutrition·C C MetgesV R Young
Sep 12, 2018·Cancers·Gabriel Valentín-GuillamaLilia Y Kucheryavykh
Aug 7, 2001·Journal of Inherited Metabolic Disease·E RiudorA Larsson
Dec 10, 2019·International Urogynecology Journal·Abubakr H MossaLysanne Campeau

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